Antimicrobial resistance: a global multifaceted phenomenon

被引:1885
作者
Prestinaci, Francesca [1 ]
Pezzotti, Patrizio [1 ]
Pantosti, Annalisa [1 ]
机构
[1] Ist Super Sanita, Dept Infect Parasit & Immunomediated Dis, Viale Regina Elena 299, I-00161 Rome, Italy
关键词
Antimicrobial resistance; Global surveillance; Antibiotic use; Veterinary medicine; MRSA; Klebsiella pneumoniae; Non-typhoidal Salmonella; Mycobaterium tuberculosis; ANTIBIOTIC-RESISTANCE; KLEBSIELLA-PNEUMONIAE; STAPHYLOCOCCUS-AUREUS; PATHOGENS RESISTANT; FOOD ANIMALS; SALMONELLA; INFECTIONS; EPIDEMIOLOGY; SPECTRUM; TUBERCULOSIS;
D O I
10.1179/2047773215Y.0000000030
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Antimicrobial resistance (AMR) is one of the most serious global public health threats in this century. The first World Health Organization (WHO) Global report on surveillance of AMR, published in April 2014, collected for the first time data from national and international surveillance networks, showing the extent of this phenomenon in many parts of the world and also the presence of large gaps in the existing surveillance. In this review, we focus on antibacterial resistance (ABR), which represents at the moment the major problem, both for the high rates of resistance observed in bacteria that cause common infections and for the complexity of the consequences of ABR. We describe the health and economic impact of ABR, the principal risk factors for its emergence and, in particular, we illustrate the highlights of four antibiotic-resistant pathogens of global concern - Staphylococcus aureus, Klebsiella pneumoniae, non-typhoidal Salmonella and Mycobacterium tuberculosis - for whom we report resistance data worldwide. Measures to control the emergence and the spread of ABR are presented.
引用
收藏
页码:309 / 318
页数:10
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