Expanding the role of umbilical cord blood transplantation

被引：106
作者：
Brunstein, Claudio G. [1 ]
Setubal, Daniela C. [1 ]
Wagner, John E. [1 ]
机构：
[1] Univ Minnesota, Blood & Marrow Transplant Program, Minneapolis, MN 55455 USA
来源：
BRITISH JOURNAL OF HAEMATOLOGY | 2007年 / 137卷 / 01期
关键词：
umbilical cord blood transplantation; non-myeloablative conditioning regimen; haematological malignancies;
D O I：
10.1111/j.1365-2141.2007.06521.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Umbilical cord blood has become a valuable alternative source of haematopoietic stem cells for allogeneic transplantation. However, largely because of the impact of cell dose on engraftment, risk of transplant-related mortality and survival, progress in the field has been largely restricted to children. Nevertheless, substantial clinical experience with umbilical cord blood transplantation clearly establishes its safety and effectiveness in young patients with a variety of malignant and non-malignant diseases. Although less well established in adults, new strategies are now being explored to address the obstacle of cell dose. This article reviews the state of the art and future directions with umbilical cord blood as a source of haematopoietic stem cells for transplantation in both children and adults.
引用
收藏
页码：20 / 35
页数：16
相关论文
共 119 条
[1]   Unrelated cord blood transplantation (UCBT) in children with sickle cell disease (SCD): US centers experience. [J].
Adamkiewicz, TV ;
Haight, A ;
Mazur, MA ;
Baker, KS ;
Szabolcs, P ;
Kedar, A ;
Chiang, KY ;
Krishnamurti, L ;
Wagner, JE ;
Wingard, JR ;
Yeager, AM .
BLOOD, 2005, 106 (11) :578A-578A
[2]  
*AM ASS BLOOD BANK, 2001, STAND UCB SERV
[3]   Umbilical cord blood transplant from unrelated HLA-mismatched donors in children with high risk leukemia [J].
Arcese, W ;
Guglielmi, C ;
Iori, AP ;
Screnci, M ;
Carmini, D ;
Testi, AM ;
Moleti, ML ;
Mengarelli, A ;
Del Giudice, I ;
Cimino, G ;
Elia, L ;
Rapanotti, MC ;
Perrone, P ;
Laurenti, L ;
Gentile, G ;
Boecklin, F ;
Romano, A ;
De Felice, L ;
Mandelli, F .
BONE MARROW TRANSPLANTATION, 1999, 23 (06) :549-554
[4]  
Arcese W, 2006, HAEMATOL-HEMATOL J, V91, P223
[5]  
Arora M, 2005, BLOOD, V106, p516A
[6]   Excellent disease-free survival after double cord blood transplantation using a reduced intensity chemotherapy only conditioning regimen in a diverse adult population. [J].
Ballen, KK ;
Spitzer, TR ;
Yeap, B ;
Steve, M ;
Dey, BR ;
Attar, E ;
Alyea, E ;
Cutler, C ;
Ho, V ;
Lee, S ;
Soiffer, R ;
Antin, JH .
BLOOD, 2005, 106 (11) :579A-580A
[7]  
BARKER J, 2004, BLOOD, V104, pA825
[8]  
Barker JN, 2005, BLOOD, V106, p813A
[9]   Transplantation of 2 partially HLA-matched umbilical cord blood units to enhance engraftment in adults with hematologic malignancy [J].
Barker, JN ;
Weisdorf, DJ ;
DeFor, TE ;
Blazar, BR ;
McGlave, PB ;
Miller, JS ;
Verfaillie, CM ;
Wagner, JE .
BLOOD, 2005, 105 (03) :1343-1347
[10]   Rapid and complete donor chimerism in adult recipients of unrelated donor umbilical cord blood transplantation after reduced-intensity conditioning [J].
Barker, JN ;
Weisdorf, DJ ;
DeFor, TE ;
Blazar, BR ;
Miller, JS ;
Wagner, JE .
BLOOD, 2003, 102 (05) :1915-1919
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