In this work, a methodology that exploits the optical properties of the nanoporous anodic alumina gradient index filters (NAA-GIFs) has been developed and applied to evaluate in real time the release dynamics of a cargo molecule, acting as a model drug, filling the pores. NAA-GIFs with two photonic stopbands (PSBs) were prepared with one of its stop bands in the same absorption wavelength range of the cargo molecule, whereas the second stopband away from this absorption range. Numerical simulation and experiments confirm that the relative height of the high reflectance bands in the reflectance spectra of NAA-GIFs filled with the drug can be related to the relative amount of drug filling the pores. This property has been applied in a flow cell setup to measure in real-time the release dynamics of NAA-GIFs with the inner pore surface modified by layer-by-layer deposition of polyelectrolytes and loaded with the cargo molecule. The methodology developed in this work acts as a tool for the study of drug delivery from porous nanostructures.
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Univ Adelaide, Sch Chem Engn, Adelaide, SA 5005, Australia
Univ Adelaide, IPAS, Adelaide, SA 5005, Australia
Univ Adelaide, ARC Ctr Excellence Nanoscale BioPhoton CNBP, Adelaide, SA 5005, AustraliaUniv Adelaide, Sch Chem Engn, Adelaide, SA 5005, Australia
Lim, Siew Yee
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Law, Cheryl Suwen
Markovic, Marijana
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Univ Adelaide, Sch Agr Food & Wine, Adelaide, SA 5064, Australia
CSIRO Land & Water, Adelaide, SA 5064, AustraliaUniv Adelaide, Sch Chem Engn, Adelaide, SA 5005, Australia
Markovic, Marijana
Kirby, Jason K.
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CSIRO Land & Water, Adelaide, SA 5064, AustraliaUniv Adelaide, Sch Chem Engn, Adelaide, SA 5005, Australia
Kirby, Jason K.
Abell, Andrew D.
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Univ Adelaide, IPAS, Adelaide, SA 5005, Australia
Univ Adelaide, ARC Ctr Excellence Nanoscale BioPhoton CNBP, Adelaide, SA 5005, Australia
Univ Adelaide, Dept Chem, Adelaide, SA 5005, AustraliaUniv Adelaide, Sch Chem Engn, Adelaide, SA 5005, Australia