Reduced prefrontal oxygenation during object and spatial visual working memory in unpolar and bipolar depression

被引：58

作者：

Schecklmann, Martin ^{[1
,2
,3
]}

Dresler, Thomas ^{[2
]}

Beck, Stefanie ^{[4
]}

Jay, Johanna T. ^{[5
]}

Febres, Richard ^{[2
]}

Haeusler, Julia ^{[3
]}

Jarczok, Tomasz A. ^{[2
]}

Reif, Andreas ^{[2
]}

Plichta, Michael M. ^{[6
]}

Ehlis, Ann-Christine ^{[2
,7
]}

Fallgatter, Andreas J. ^{[2
,7
]}

机构：

[1] Univ Regensburg, Dept Psychiat & Psychotherapy, D-93053 Regensburg, Germany

[2] Univ Wurzburg, Dept Psychiat Psychosomat & Psychotherapy, Wurzburg, Germany

[3] Univ Wurzburg, Dept Child & Adolescent Psychiat, Wurzburg, Germany

[4] Charite, Dept Anesthesiol & Operat Intens Care Med, D-13353 Berlin, Germany

[5] Missionsarztliche Klin Wurzburg, Wurzburg, Germany

[6] Cent Inst Mental Hlth, D-6800 Mannheim, Germany

[7] Univ Tubingen, Dept Psychiat & Psychotherapy, Tubingen, Germany

来源：

PSYCHIATRY RESEARCH-NEUROIMAGING | 2011年 / 194卷 / 03期

关键词：

Functional near-infrared spectroscopy; Affective disorders; Executive functions; NEAR-INFRARED SPECTROSCOPY; VERBAL-FLUENCY TASK; UNIPOLAR DEPRESSION; MAJOR DEPRESSION; NEURAL SYSTEMS; ACTIVATION; DISORDER; BRAIN; FMRI; BACK;

D O I：

10.1016/j.pscychresns.2011.01.016

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Altered prefrontal brain activity (e.g. hypofrontality) during cognitive tasks such as working memory is a core neuroimaging marker in unipolar (UNI) and bipolar (BI) depression. The present study investigated for the first time UNI (n = 16) and BI patients (n = 14) in a working memory task including different processes (storage and matching) and components (object and spatial visual) with functional near-infrared spectroscopy (fNIRS) over the prefrontal cortex. In healthy controls (n = 15) comparable to both patient groups, changes of oxygenated and deoxygenated haemoglobin indicated increased ventro-lateral, dorso-lateral prefrontal and superior frontal cortex activity for object and spatial visual working memory storage as compared to the control condition. In contrast, both patient groups showed diminished brain activity in all working memory conditions. Results revealed unspecific deficits that did not allow the differentiation between unipolar and bipolar depression in dependence of working memory processes or components. However, fNIRS can be considered as a valid, easy manageable, low cost and rapid tool for measuring (diminished) prefrontal cortex functions. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

引用

页码：378 / 384

页数：7

共 52 条

[1] Changes in neuronal activation in patients with bipolar disorder during performance of a working memory task [J].