Increased hippocampal atrophy rates in AD over 6 months using serial MR imaging

被引：22

作者：

Barnes, J. ^{[1
]}

Scahill, R. I. ^{[1
]}

Frost, C. ^{[1
,2
]}

Schott, J. M. ^{[1
]}

Rossor, M. N. ^{[1
,3
]}

Fox, N. C. ^{[1
]}

机构：

[1] UCL, Inst Neurol, Dementia Res Ctr, London, England

[2] London Sch Hyg & Trop Med, London WC1, England

[3] Univ London Imperial Coll Sci Technol & Med, Div Neurosci & Psychol Med, Fac Med, London, England

来源：

NEUROBIOLOGY OF AGING | 2008年 / 29卷 / 08期

基金：

英国医学研究理事会;

关键词：

hippocampus; atrophy rate; scanning interval; Alzheimer's disease; MRI;

D O I：

10.1016/j.neurobiolaging.2007.02.011

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

We measured hippocampi on baseline-, 6- and 12-month scans in a group of AD (n = 36) and control subjects (n = 20). We found that mean annualised atrophy rates using 6-month intervals were comparable at a group level to those generated from a 12-month interval. Higher variance was seen using shorter intervals, although this was only significant in the control group. This has implications where shorter inter-scan intervals may be advantageous, such as rapid diagnosis, and tracking of disease progression including in a clinical trial. (c) 2007 Elsevier Inc. All rights reserved.

引用

页码：1199 / 1203

页数：5

共 14 条

[1] Serial brain MRI at 3-6 month intervals as a surrogate marker for Alzheimer's disease [J].