Positive Effects of Vitamin D Supplementation in Patients Hospitalized for COVID-19: A Randomized, Double-Blind, Placebo-Controlled Trial

被引：59

作者：

De Niet, Sophie ^{[1
]}

Tremege, Mickael ^{[1
]}

Coffiner, Monte ^{[1
]}

Rousseau, Anne-Francoise ^{[2
]}

Calmes, Doriane ^{[3
]}

Frix, Anne-Noelle ^{[3
]}

Gester, Fanny ^{[3
]}

Delvaux, Muriel ^{[3
]}

Dive, Anne-Francoise ^{[3
]}

Guglielmi, Elora ^{[3
]}

Henket, Monique ^{[3
]}

Staderoli, Alicia ^{[3
]}

Maesen, Didier ^{[4
]}

Louis, Renaud ^{[3
]}

Guiot, Julien ^{[3
]}

Cavalier, Etienne ^{[5
]}

机构：

[1] Labs SMB SA, Clin Dept, B-1080 Brussels, Belgium

[2] Univ Liege, Dept Intens Care, CHU Sart Tilman, B-4000 Liege, Belgium

[3] Univ Liege, Dept Pneumol & Allergol, CHU Sart Tilman, B-4000 Liege, Belgium

[4] CHU Sart Tilman, Dept Hosp Pharm, B-4000 Liege, Belgium

[5] Univ Liege, Dept Clin Chem, CHU Sart Tilman, CIRM, B-4000 Liege, Belgium

来源：

NUTRIENTS | 2022年 / 14卷 / 15期

关键词：

vitamin D; cholecalciferol; calcifediol; COVID-19; SARS-CoV-2; hospitalization; 25-HYDROXYVITAMIN D; 25(OH)-VITAMIN D; D DEFICIENCY; IMMUNOASSAYS; ASSOCIATION; INFECTIONS; EXPRESSION; IMMUNITY; INNATE;

D O I：

10.3390/nu14153048

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Retrospective studies showed a relationship between vitamin D status and COVID-19 severity and mortality, with an inverse relation between SARS-CoV-2 positivity and circulating calcifediol levels. The objective of this pilot study was to investigate the effect of vitamin D supplementation on the length of hospital stay and clinical improvement in patients with vitamin D deficiency hospitalized with COVID-19. The study was randomized, double blind and placebo controlled. A total of 50 subjects were enrolled and received, in addition to the best available COVID therapy, either vitamin D (25,000 IU per day over 4 consecutive days, followed by 25,000 IU per week up to 6 weeks) or placebo. The length of hospital stay decreased significantly in the vitamin D group compared to the placebo group (4 days vs. 8 days; p = 0.003). At Day 7, a significantly lower percentage of patients were still hospitalized in the vitamin D group compared to the placebo group (19% vs. 54%; p = 0.0161), and none of the patients treated with vitamin D were hospitalized after 21 days compared to 14% of the patients treated with placebo. Vitamin D significantly reduced the duration of supplemental oxygen among the patients who needed it (4 days vs. 7 days in the placebo group; p = 0.012) and significantly improved the clinical recovery of the patients, as assessed by the WHO scale (p = 0.0048). In conclusion, this study demonstrated that the clinical outcome of COVID-19 patients requiring hospitalization was improved by administration of vitamin D.

引用

页数：12

共 47 条

[1] The role of UV radiation and vitamin D in the seasonality and outcomes of infectious disease [J].