Chemoenzymatic One-Pot Synthesis of γ-Butyrolactones

被引：44
|
作者：
Korpak, Margarete [1 ]
Pietruszka, Joerg [1 ]
机构：
[1] Univ Dusseldorf, Inst Bioorgan Chem, Forschungszentrum Julich, D-52426 Julich, Germany
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2011年 / 353卷 / 09期
关键词：
alcohol dehydrogenase; asymmetric catalysis; asymmetric synthesis; ene reductase; enzymes; reduction; OLD YELLOW ENZYME; ASYMMETRIC BIOREDUCTION; ENOATE REDUCTASES; NATURAL-PRODUCT; NITROALKENES; REDUCTIONS; EXPRESSION; REVISION; CLONING; METHYL;
D O I：
10.1002/adsc.201100110
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
The synthesis of enantio- and diastereomerically pure gamma-butyrolactones is described using a one-pot, two-enzyme cascade. Ethyl 2-methyl-4-oxopent-2-enoate (2) was reduced selectively first in a 1,4-reduction using the old yellow enzyme (OYE1) [EC 1.6.99.1] and consecutively in a 1,2-reduction by an alcohol dehydrogenase [EC 1.1.1.2].
引用
收藏
页码：1420 / 1424
页数：5
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