Chemoenzymatic One-Pot Synthesis of γ-Butyrolactones

被引：44

作者：

Korpak, Margarete ^{[1
]}

Pietruszka, Joerg ^{[1
]}

机构：

[1] Univ Dusseldorf, Inst Bioorgan Chem, Forschungszentrum Julich, D-52426 Julich, Germany

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2011年 / 353卷 / 09期

关键词：

alcohol dehydrogenase; asymmetric catalysis; asymmetric synthesis; ene reductase; enzymes; reduction; OLD YELLOW ENZYME; ASYMMETRIC BIOREDUCTION; ENOATE REDUCTASES; NATURAL-PRODUCT; NITROALKENES; REDUCTIONS; EXPRESSION; REVISION; CLONING; METHYL;

D O I：

10.1002/adsc.201100110

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The synthesis of enantio- and diastereomerically pure gamma-butyrolactones is described using a one-pot, two-enzyme cascade. Ethyl 2-methyl-4-oxopent-2-enoate (2) was reduced selectively first in a 1,4-reduction using the old yellow enzyme (OYE1) [EC 1.6.99.1] and consecutively in a 1,2-reduction by an alcohol dehydrogenase [EC 1.1.1.2].

引用

页码：1420 / 1424

页数：5

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