Wearable aptamer-field-effect transistor sensing system for noninvasive cortisol monitoring

被引：264

作者：

Wang, Bo ^{[1
]}

Zhao, Chuanzhen ^{[2
,3
]}

Wang, Zhaoqing ^{[1
]}

Yang, Kyung-Ae ^{[4
]}

Cheng, Xuanbing ^{[1
,5
]}

Liu, Wenfei ^{[2
,3
]}

Yu, Wenzhuo ^{[1
]}

Lin, Shuyu ^{[1
]}

Zhao, Yichao ^{[1
,5
]}

Cheung, Kevin M. ^{[2
,3
]}

Lin, Haisong ^{[1
]}

Hojaiji, Hannaneh ^{[1
]}

Weiss, Paul S. ^{[2
,3
,5
,6
]}

Stojanovic, Milan N. ^{[4
,7
]}

Tomiyama, A. Janet ^{[8
]}

Andrews, Anne M. ^{[2
,3
,9
,10
,11
]}

Emaminejad, Sam ^{[1
,6
]}

机构：

[1] Univ Calif Los Angeles, Dept Elect & Comp Engn, Interconnected & Integrated Bioelect Lab I2BL, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Dept Chem & Biochem, Los Angeles, CA 90095 USA

[3] Univ Calif Los Angeles, Calif NanoSyst Inst, Los Angeles, CA 90095 USA

[4] Columbia Univ, Dept Med, Div Expt Therapeut, New York, NY 10032 USA

[5] Univ Calif Los Angeles, Dept Mat Sci & Engn, Los Angeles, CA 90095 USA

[6] Univ Calif Los Angeles, Dept Bioengn, Los Angeles, CA 90095 USA

[7] Columbia Univ, Dept Biomed Engn, New York, NY 10032 USA

[8] Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA 90095 USA

[9] Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90095 USA

[10] Univ Calif Los Angeles, Semel Inst Neurosci & Human Behav, Los Angeles, CA 90095 USA

[11] Univ Calif Los Angeles, Hatos Ctr Neuropharmacol, Los Angeles, CA 90095 USA

来源：

SCIENCE ADVANCES | 2022年 / 8卷 / 01期

基金：

美国国家科学基金会;

关键词：

SALIVARY CORTISOL; ECCRINE SWEAT; IMMUNOASSAYS; PERSPIRATION; DEPRESSION; BIOMARKERS; DIAGNOSIS; ANXIETY; SENSORS; SERUM;

D O I：

10.1126/sciadv.abk0967

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Wearable technologies for personalized monitoring require sensors that track biomarkers often present at low levels. Cortisol-a key stress biomarker-is present in sweat at low nanomolar concentrations. Previous wearable sensing systems are limited to analytes in the micromolar-millimolar ranges. To overcome this and other limitations, we developed a flexible field-effect transistor (FET) biosensor array that exploits a previously unreported cortisol aptamer coupled to nanometer-thin-film In2O3 FETs. Cortisol levels were determined via molecular recognition by aptamers where binding was transduced to electrical signals on FETs. The physiological relevance of cortisol as a stress biomarker was demonstrated by tracking salivary cortisol levels in participants in a Trier Social Stress Test and establishing correlations between cortisol in diurnal saliva and sweat samples. These correlations motivated the development and on-body validation of an aptamer-FET array-based smartwatch equipped with a custom, multichannel, self-referencing, and autonomous source measurement unit enabling seamless, real-time cortisol sweat sensing.

引用

页数：15

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