Wearable aptamer-field-effect transistor sensing system for noninvasive cortisol monitoring

被引：264

作者：

Wang, Bo ^{[1
]}

Zhao, Chuanzhen ^{[2
,3
]}

Wang, Zhaoqing ^{[1
]}

Yang, Kyung-Ae ^{[4
]}

Cheng, Xuanbing ^{[1
,5
]}

Liu, Wenfei ^{[2
,3
]}

Yu, Wenzhuo ^{[1
]}

Lin, Shuyu ^{[1
]}

Zhao, Yichao ^{[1
,5
]}

Cheung, Kevin M. ^{[2
,3
]}

Lin, Haisong ^{[1
]}

Hojaiji, Hannaneh ^{[1
]}

Weiss, Paul S. ^{[2
,3
,5
,6
]}

Stojanovic, Milan N. ^{[4
,7
]}

Tomiyama, A. Janet ^{[8
]}

Andrews, Anne M. ^{[2
,3
,9
,10
,11
]}

Emaminejad, Sam ^{[1
,6
]}

机构：

[1] Univ Calif Los Angeles, Dept Elect & Comp Engn, Interconnected & Integrated Bioelect Lab I2BL, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Dept Chem & Biochem, Los Angeles, CA 90095 USA

[3] Univ Calif Los Angeles, Calif NanoSyst Inst, Los Angeles, CA 90095 USA

[4] Columbia Univ, Dept Med, Div Expt Therapeut, New York, NY 10032 USA

[5] Univ Calif Los Angeles, Dept Mat Sci & Engn, Los Angeles, CA 90095 USA

[6] Univ Calif Los Angeles, Dept Bioengn, Los Angeles, CA 90095 USA

[7] Columbia Univ, Dept Biomed Engn, New York, NY 10032 USA

[8] Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA 90095 USA

[9] Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90095 USA

[10] Univ Calif Los Angeles, Semel Inst Neurosci & Human Behav, Los Angeles, CA 90095 USA

[11] Univ Calif Los Angeles, Hatos Ctr Neuropharmacol, Los Angeles, CA 90095 USA

来源：

SCIENCE ADVANCES | 2022年 / 8卷 / 01期

基金：

美国国家科学基金会;

关键词：

SALIVARY CORTISOL; ECCRINE SWEAT; IMMUNOASSAYS; PERSPIRATION; DEPRESSION; BIOMARKERS; DIAGNOSIS; ANXIETY; SENSORS; SERUM;

D O I：

10.1126/sciadv.abk0967

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Wearable technologies for personalized monitoring require sensors that track biomarkers often present at low levels. Cortisol-a key stress biomarker-is present in sweat at low nanomolar concentrations. Previous wearable sensing systems are limited to analytes in the micromolar-millimolar ranges. To overcome this and other limitations, we developed a flexible field-effect transistor (FET) biosensor array that exploits a previously unreported cortisol aptamer coupled to nanometer-thin-film In2O3 FETs. Cortisol levels were determined via molecular recognition by aptamers where binding was transduced to electrical signals on FETs. The physiological relevance of cortisol as a stress biomarker was demonstrated by tracking salivary cortisol levels in participants in a Trier Social Stress Test and establishing correlations between cortisol in diurnal saliva and sweat samples. These correlations motivated the development and on-body validation of an aptamer-FET array-based smartwatch equipped with a custom, multichannel, self-referencing, and autonomous source measurement unit enabling seamless, real-time cortisol sweat sensing.

引用

页数：15

共 83 条

[1] Prospective associations between the cortisol awakening response and first onsets of anxiety disorders over a six-year follow-up-2013 Curt Richter Award Winner [J].

Adam, Emma K. ;

Vrshek-Schallhorn, Suzanne ;

Kendall, Ashley D. ;

Mineka, Susan ;

Zinbarg, Richard E. ;

Craske, Michelle G. .

PSYCHONEUROENDOCRINOLOGY, 2014, 44 :47-59

[2] Collective hormonal profiles predict group performance [J].

Akinola, Modupe ;

Page-Gould, Elizabeth ;

Mehta, Pranjal H. ;

Lu, Jackson G. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2016, 113 (35) :9774-9779

[3] Highly Scalable, Uniform, and Sensitive Biosensors Based on Top-Down Indium Oxide Nanoribbons and Electronic Enzyme-Linked Immunosorbent Assay [J].

Aroonyadet, Noppadol ;

Wang, Xiaoli ;

Song, Yan ;

Chen, Haitian ;

Cote, Richard J. ;

Thompson, Mark E. ;

Datar, Ram H. ;

Zhou, Chongwu .

NANO LETTERS, 2015, 15 (03) :1943-1951

[4]

Baker BR, 2006, J AM CHEM SOC, V128, P3138, DOI 10.1021/ja056957p

[5] The Trier Social Stress Test Protocol for Inducing Psychological Stress [J].

Birkett, Melissa A. .

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 2011, (56) :1-6

[6] Effects of mindfulness exercises as stand-alone intervention on symptoms of anxiety and depression: Systematic review and meta-analysis [J].

Blanck, Paul ;

Perleth, Sarah ;

Heidenreich, Thomas ;

Kroeger, Paula ;

Ditzen, Beate ;

Bents, Hinrich ;

Mander, Johannes .

BEHAVIOUR RESEARCH AND THERAPY, 2018, 102 :25-35

[7] Quasi-Two-Dimensional Metal Oxide Semiconductors Based Ultrasensitive Potentiometric Biosensors [J].

Chen, Huajun ;

Rim, You Seung ;

Wang, Isaac Caleb ;

Li, Chao ;

Zhu, Bowen ;

Sun, Mo ;

Goorsky, Mark S. ;

He, Ximin ;

Yang, Yang .

ACS NANO, 2017, 11 (05) :4710-4718

[8] Battery-free, wireless, and flexible electrochemical patch for in situ analysis of sweat cortisol via near field communication [J].

Cheng, Chen ;

Li, Xin ;

Xu, Gang ;

Lu, Yanli ;

Low, Sze Shin ;

Liu, Guang ;

Zhu, Long ;

Li, Caidong ;

Liu, Qingjun .

BIOSENSORS & BIOELECTRONICS, 2021, 172

[9] A Mediator-Free Electroenzymatic Sensing Methodology to Mitigate Ionic and Electroactive Interferents' Effects for Reliable Wearable Metabolite and Nutrient Monitoring [J].

Cheng, Xuanbing ;

Wang, Bo ;

Zhao, Yichao ;

Hojaiji, Hannaneh ;

Lin, Shuyu ;

Shih, Ryan ;

Lin, Haisong ;

Tamayosa, Stephanie ;

Ham, Brittany ;

Stout, Phoenix ;

Salahi, Kamyar ;

Wang, Zhaoqing ;

Zhao, Chuanzhen ;

Tan, Jiawei ;

Emaminejad, Sam .

ADVANCED FUNCTIONAL MATERIALS, 2020, 30 (10)

[10] Phenylalanine Monitoring via Aptamer-Field-Effect Transistor Sensors [J].

Cheung, Kevin M. ;

Yang, Kyung-Ae ;

Nakatsuka, Nako ;

Zhao, Chuanzhen ;

Ye, Mao ;

Jung, Michael E. ;

Yang, Hongyan ;

Weiss, Paul S. ;

Stojanovic, Milan N. ;

Andrews, Anne M. .

ACS SENSORS, 2019, 4 (12) :3308-3317

← 1 2 3 4 5 6 7 8 9 →