Solvent effects on the asymmetric Pauson-Khand-type reaction by rhodium

被引：15

作者：

Choi, Yun Hee ^{[1
]}

Kwak, Jaesung ^{[1
]}

Jeong, Nakcheol ^{[1
]}

机构：

[1] Korea Univ, Dept Chem, Seoul 136701, South Korea

来源：

TETRAHEDRON LETTERS | 2009年 / 50卷 / 44期

关键词：

Pauson-Khand reaction; Enantioselective; Rhodium; Chiral THF derivatives;

D O I：

10.1016/j.tetlet.2009.08.060

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reaction efficiency and enantioselectivity of an asymmetric Pauson-Khand-type reaction catalyzed by cationic rhodium are heavily dependent on the solvent. Coordinating solvents, such as THF, provide a faster reaction and better stereoselectivity than non-coordinating solvents, such as toluene. These beneficial effects can be attributed to a significant increase in the more reactive catalytic species of [Rh(bisphosphane ligand)*(solvent)(n)](+) (3) than of [Rh(bisphosphine ligand)*CO(solvent)](+)(4) and [Rh(bisphosphine ligand)*(CO)(2)](+) (5) in a coordinating solvent. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：6068 / 6071

页数：4

共 25 条

[1] The Pauson-Khand reaction, a powerful synthetic tool for the synthesis of complex molecules [J].