Positive and negative regulation of muscle cell identity by members of the hedgehog and TGF-beta gene families

被引:168
作者
Du, SJ
Devoto, SH
Westerfield, M
Moon, RT
机构
[1] UNIV WASHINGTON,HOWARD HUGHES MED INST,SCH MED,SEATTLE,WA 98195
[2] UNIV WASHINGTON,DEPT PHARMACOL,SCH MED,SEATTLE,WA 98195
[3] UNIV OREGON,INST NEUROSCI,EUGENE,OR 97403
关键词
D O I
10.1083/jcb.139.1.145
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
We have examined whether the development of embryonic muscle fiber type is regulated by competing influences between Hedgehog and TGF-beta signals, as previously shown for development of neuronal cell identity in the neural tube. We found that ectopic expression of Hedgehogs or inhibition of protein kinase A in zebrafish embryos induces slow muscle precursors throughout the somite but muscle pioneer cells only in the middle of the somite. Ectopic expression in the notochord of Dorsalin-1, a member of the TGF-beta superfamily, inhibits the formation of muscle pioneer cells, demonstrating that TGF-beta signals can antagonize the induction of muscle pioneer cells by Hedgehog. We propose that a Hedgehog signal first induces the formation of slow muscle precursor cells, and subsequent Hedgehog and TGF-beta signals exert competing positive and negative influences on the development of muscle pioneer cells.
引用
收藏
页码:145 / 156
页数:12
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