A framework based on fundamental biochemical principles to engineer microbial community dynamics

被引：9
作者：
Gonzalez-Cabaleiro, Rebeca [1 ]
Martinez-Rabert, Eloi [1 ]
Argiz, Lucia [2 ]
van Kessel, Maartje A. H. J. [3 ]
Smith, Cindy J. [1 ]
机构：
[1] Univ Glasgow, James Watt Sch Engn, Infrastruct & Environm Res Div, Rankine Bldg, Glasgow G12 8LT, Lanark, Scotland
[2] Univ Santiago de Compostela, CRETUS Inst, Dept Chem Engn, Santiago De Compostela 15782, Galicia, Spain
[3] Radboud Univ Nijmegen, Inst Water & Wetland Res, Dept Microbiol, Nijmegen, Netherlands
来源：
CURRENT OPINION IN BIOTECHNOLOGY | 2021年 / 67卷
基金：
英国工程与自然科学研究理事会;
关键词：
CULTURES; SLUDGE; LABOR;
D O I：
10.1016/j.copbio.2021.01.001
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Microbial communities are complex but there are basic principles we can apply to constrain the assumed stochasticity of their activity. By understanding the trade-offs behind the kinetic parameters that define microbial growth, we can explain how local interspecies dependencies arise and shape the emerging properties of a community. If we integrate these theoretical descriptions with experimental 'omics' data and bioenergetics analysis of specific environmental conditions, predictions on activity, assembly and spatial structure can be obtained reducing the a priori unpredictable complexity of microbial communities. This information can be used to define the appropriate selective pressures to engineer bioprocesses and propose new hypotheses which can drive experimental research to accelerate innovation in biotechnology.
引用
收藏
页码：111 / 118
页数：8
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