Antioxidant-Based Therapies in Male Infertility: Do We Have Sufficient Evidence Supporting Their Effectiveness?

被引:17
作者
Amorini, Angela Maria [1 ]
Listorti, Ilaria [2 ]
Bilotta, Gabriele [2 ]
Pallisco, Romina [2 ]
Saab, Miriam Wissam [1 ]
Mangione, Renata [3 ]
Manca, Benedetta [4 ]
Lazzarino, Giacomo [3 ,5 ]
Tavazzi, Barbara [3 ,6 ]
Lazzarino, Giuseppe [1 ,7 ]
Bilotta, Pasquale [8 ]
机构
[1] Univ Catania, Div Med Biochem, Dept Biomed & Biotechnol Sci, Via S Sofia 97, I-95123 Catania, Italy
[2] Alma Res Fertil Ctr, Lab Biol & Embriol, Via Parenzo 12, I-00199 Rome, Italy
[3] Catholic Univ Sacred Heart Rome, Dept Basic Biotechnol Sci Intens & Perioperat Cli, Largo F Vito 1, I-00168 Rome, Italy
[4] Univ Bologna, Dept Pharm & Biotechnol FaBiT, Via Irnerio 48, I-40126 Bologna, Italy
[5] UniCamillus St Camillus Int Univ Hlth Sci, Via St Alessandro 8, I-00131 Rome, Italy
[6] Fdn Policlin Univ A Gemelli IRCCS, Largo A Gemelli 8, I-00168 Rome, Italy
[7] LTA Biotech Srl, Viale Don Orione 3D, I-95047 Paterno, Italy
[8] Alma Res Fertil Ctr, Lab Obstet & Ginecol, Via Parenzo 12, I-00199 Rome, Italy
关键词
male infertility; oxidative; nitrosative stress; antioxidants; seminal plasma; spermatozoa; HUMAN SEMINAL PLASMA; HUMAN SPERM DNA; COENZYME Q(10) SUPPLEMENTATION; EJACULATORY DUCT OBSTRUCTION; CONGENITAL BILATERAL ABSENCE; IDIOPATHIC MALE-INFERTILITY; VITAMIN-E SUPPLEMENTATION; OXYGEN SPECIES PRODUCTION; OXIDATIVE STRESS MARKERS; TRAUMATIC BRAIN-INJURY;
D O I
10.3390/antiox10020220
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Under physiological conditions, reactive oxygen species (ROS) play pivotal roles in various processes of human spermatozoa. Indeed, semen requires the intervention of ROS to accomplish different stages of its maturation. However, ROS overproduction is a well-documented phenomenon occurring in the semen of infertile males, potentially causing permanent oxidative damages to a vast number of biological molecules (proteins, nucleic acids, polyunsaturated fatty acids of biological membrane lipids), negatively affecting the functionality and vitality of spermatozoa. ROS overproduction may concomitantly occur to the excess generation of reactive nitrogen species (RNS), leading to oxidative/nitrosative stress and frequently encountered in various human pathologies. Under different conditions of male infertility, very frequently accompanied by morpho-functional anomalies in the sperm analysis, several studies have provided evidence for clear biochemical signs of damages to biomolecules caused by oxidative/nitrosative stress. In the last decades, various studies aimed to verify whether antioxidant-based therapies may be beneficial to treat male infertility have been carried out. This review analyzed the results of the studies published during the last ten years on the administration of low-molecular-weight antioxidants to treat male infertility in order to establish whether there is a sufficient number of data to justify antioxidant administration to infertile males. An analysis of the literature showed that only 30 clinical studies tested the effects of the administration of low-molecular-weight antioxidants (administered as a single antioxidant or as a combination of different antioxidants with the addition of vitamins and/or micronutrients) to infertile males. Of these studies, only 33.3% included pregnancy and/or live birth rates as an outcome measure to determine the effects of the therapy. Of these studies, only 4 were case-control studies, and only 2 of them found improvement of the pregnancy rate in the group of antioxidant-treated patients. Additionally, of the 30 studies considered in this review, only 43.3% were case-control studies, 66.7% enrolled a number of patients higher than 40, and 40% carried out the administration of a single antioxidant. Therefore, it appears that further studies are needed to clearly define the usefulness of antioxidant-based therapies to treat male infertility.
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页码:1 / 30
页数:31
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