The Pathophysiology of Septic Shock

被引：67

作者：

Nduka, O. Okorie ^{[1
,2
]}

Parrillo, Joseph E. ^{[3
]}

机构：

[1] Cooper Univ Hosp, Dept Internal Med, Div Crit Care Med, Camden, NJ USA

[2] Altru Hosp, Grand Forks, ND 58206 USA

[3] Univ Med & Dent New Jersey, Dept Med, Robert Wood Johnson Med Sch, Newark, NJ 07103 USA

来源：

CRITICAL CARE CLINICS | 2009年 / 25卷 / 04期

关键词：

Sepsis; Severe sepsis; Septic shock; Myocardial depression; Vasodilation; CHOLINERGIC ANTIINFLAMMATORY PATHWAY; KAPPA-B ACTIVATION; HOST-PATHOGEN INTERACTIONS; TUMOR-NECROSIS-FACTOR; INNATE IMMUNITY; PSEUDOMONAS-AERUGINOSA; ACTIN CYTOSKELETON; RHO GTPASES; SEPSIS; INFLAMMATION;

D O I：

10.1016/j.ccc.2009.08.002

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

There is a profound cellular dysfunction in sepsis, that clinically manifests as a continuum from simple, uncomplicated sepsis to severe sepsis, and finally to septic shock. Septic shock remains a significant challenge for clinicians. Recent advances in cellular and molecular biology have significantly improved our understanding of its pathogenetic mechanisms. These improvements will translate to better care and improved outcomes for these patients.

引用

页码：677 / +

页数：27

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