Ageing as a risk factor for neurodegenerative disease

被引：2134

作者：

Hou, Yujun ^{[1
]}

Dan, Xiuli ^{[1
]}

Babbar, Mansi ^{[1
]}

Wei, Yong ^{[1
]}

Hasselbalch, Steen G. ^{[2
]}

Croteau, Deborah L. ^{[1
]}

Bohr, Vilhelm A. ^{[1
,3
]}

机构：

[1] NIA, Lab Mol Gerontol, NIH, Baltimore, MD 21224 USA

[2] Univ Copenhagen, Rigshosp, Danish Dementia Res Ctr, Copenhagen, Denmark

[3] Univ Copenhagen, Ctr Hlth Aging, Copenhagen, Denmark

来源：

NATURE REVIEWS NEUROLOGY | 2019年 / 15卷 / 10期

关键词：

BASE EXCISION-REPAIR; AMYOTROPHIC-LATERAL-SCLEROSIS; ALZHEIMERS-DISEASE; MOUSE MODEL; DNA-DAMAGE; CELLULAR SENESCENCE; PARKINSONS-DISEASE; OXIDATIVE STRESS; LIFE-SPAN; MITOCHONDRIAL DYSFUNCTION;

D O I：

10.1038/s41582-019-0244-7

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Ageing is the primary risk factor for most neurodegenerative diseases, including Alzheimer disease (AD) and Parkinson disease (PD). One in ten individuals aged >= 65 years has AD and its prevalence continues to increase with increasing age. Few or no effective treatments are available for ageing-related neurodegenerative diseases, which tend to progress in an irreversible manner and are associated with large socioeconomic and personal costs. This Review discusses the pathogenesis of AD, PD and other neurodegenerative diseases, and describes their associations with the nine biological hallmarks of ageing: genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, mitochondrial dysfunction, cellular senescence, deregulated nutrient sensing, stem cell exhaustion and altered intercellular communication. The central biological mechanisms of ageing and their potential as targets of novel therapies for neurodegenerative diseases are also discussed, with potential therapies including NAD(+) precursors, mitophagy inducers and inhibitors of cellular senescence.

引用

页码：565 / 581

页数：17

共 207 条

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