Viral and Inflammatory Triggers of Neurodegenerative Diseases

被引：80

作者：

Deleidi, Michela ^{[1
,2
]}

Isacson, Ole ^{[1
,2
,3
,4
]}

机构：

[1] Harvard Univ, Sch Med, Boston, MA 02115 USA

[2] McLean Hosp, Neuroregenerat Labs, Belmont, MA 02478 USA

[3] Harvard NeuroDiscovery Ctr, Boston, MA 02115 USA

[4] Harvard Stem Cell Inst, Cambridge, MA 02138 USA

来源：

SCIENCE TRANSLATIONAL MEDICINE | 2012年 / 4卷 / 121期

关键词：

TOLL-LIKE RECEPTOR-3; CENTRAL-NERVOUS-SYSTEM; H5N1; INFLUENZA-VIRUS; PARKINSONS-DISEASE; NEGATIVE REGULATOR; ENCEPHALITIS; DEGENERATION; EXPRESSION; NEUROINFLAMMATION; INFECTION;

D O I：

10.1126/scitranslmed.3003492

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Here, we synthesize research behind the emerging hypothesis that inflammation-which can result, for example, from viral infections-can initiate and propagate chronic neuronal dysfunction, an event that precedes the clinical onset of many neurodegenerative diseases. Therapeutic approaches that target immunological pathways in the prodromal phase of diseases might decrease the incidence of neurodegenerative disorders and increase the therapeutic window for neuroprotection.

引用

页数：5

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