Pharmacological manipulation of memory reconsolidation: Towards a novel treatment of pathogenic memories

被引：55
作者：
Diergaarde, Leontien [1 ]
Schoffelmeer, Anton N. M. [1 ]
De Vries, Taco J. [1 ]
机构：
[1] Vrije Univ Amsterdam Med Ctr, Dept Anat & Neurosci, Ctr Neurogenom & Cognit Res, NL-1081 BT Amsterdam, Netherlands
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 2008年 / 585卷 / 2-3期
关键词：
memory; addiction; post-traumatic stress disorder; therapy; rat; mouse;
D O I：
10.1016/j.ejphar.2008.03.010
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Well-consolidated memories, when retrieved, may return to a transiently fragile state, and need to be consolidated again in order to be maintained. This process has been referred to as memory reconsolidation and presumably serves to modify or strengthen memory traces. In recent years, our understanding of the neurobiological mechanisms underlying this phenomenon has increased rapidly. Here, we will briefly review some of the pharmacological evidence, stressing a crucial role for the brain's major neurotransmitter systems, such as glutamate and noradrenaline, in memory reconsolidation. Pharmacological intervention of reconsolidation processes may have clinical relevance, especially for the treatment of psychiatric disorders that are characterized by pathological memories, including post-traumatic stress disorder and addictive behaviour. (C) 2008 Elsevier B.V. All rights reserved.
引用
收藏
页码：453 / 457
页数：5
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