Synthesis and anti-microbial activities of choline-like quaternary ammonium chlorides

被引：102
|
作者：
Pernak, J [1 ]
Chwala, P [1 ]
机构：
[1] Poznan Univ Tech, PL-60965 Poznan, Poland
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2003年 / 38卷 / 11-12期
关键词：
quaternary ammonium chlorides; deanol; anti-microbial activities; QSAR analysis;
D O I：
10.1016/j.ejmech.2003.09.004
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
New choline-like quaternary ammonium chlorides were obtained. The work-up procedure of synthesis was quick and efficient. The obtained chlorides showed anti-microbial activities. Quaternary ammonium chlorides derivatives of deanol esters exhibited strong activity and wide anti-bacterial spectra, similar to the activity of benzalkonium chloride. The relationship between chemical structure and anti-microbial activity was analyzed by the QSAR method. (C) 2003 Editions scientifiques et medicales Elsevier SAS. All rights reserved.
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页码：1035 / 1042
页数：8
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