Synthesis and anti-microbial activities of choline-like quaternary ammonium chlorides

被引：102

作者：

Pernak, J ^{[1
]}

Chwala, P ^{[1
]}

机构：

[1] Poznan Univ Tech, PL-60965 Poznan, Poland

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2003年 / 38卷 / 11-12期

关键词：

quaternary ammonium chlorides; deanol; anti-microbial activities; QSAR analysis;

D O I：

10.1016/j.ejmech.2003.09.004

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

New choline-like quaternary ammonium chlorides were obtained. The work-up procedure of synthesis was quick and efficient. The obtained chlorides showed anti-microbial activities. Quaternary ammonium chlorides derivatives of deanol esters exhibited strong activity and wide anti-bacterial spectra, similar to the activity of benzalkonium chloride. The relationship between chemical structure and anti-microbial activity was analyzed by the QSAR method. (C) 2003 Editions scientifiques et medicales Elsevier SAS. All rights reserved.

引用

页码：1035 / 1042

页数：8

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