Surface CD3-negative monomorphic epitheliotropic intestinal T-cell lymphoma

被引：2

作者：

Domoto, Hideharu ^{[1
]}

Araki, Takahiro ^{[2
]}

Ogai, Asuka ^{[2
]}

Inukai, Michiko ^{[3
]}

Chen, Chien K. ^{[2
]}

Tomita, Sakura ^{[4
]}

Mukai, Kiyoshi ^{[1
]}

Nakamura, Naoya ^{[4
]}

机构：

[1] Keiyu Hosp, Dept Diagnost Pathol, Yokohama, Kanagawa, Japan

[2] Keiyu Hosp, Dept Hematol, Yokohama, Kanagawa, Japan

[3] Keiyu Hosp, Dept Surg, Yokohama, Kanagawa, Japan

[4] Tokai Univ, Sch Med, Dept Pathol Diagnost, Isehara, Kanagawa, Japan

来源：

JOURNAL OF CLINICAL AND EXPERIMENTAL HEMATOPATHOLOGY | 2022年 / 62卷 / 03期

关键词：

monomorphic epitheliotropic intestinal T; cell lymphoma; intestinal T/NK; surface CD3; flowcytometry; CD38; EXPRESSION; FLOW-CYTOMETRY; ENTEROPATHY;

D O I：

10.3960/jslrt.22005

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Intestinal T/NK-cell lymphomas include enteropathy-associated T-cell lymphoma (EATL), monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL), indolent T- cell lymphoproliferative disorders of the GI tract (ITCLPD), extranodal NK/T- cell lymphoma, nasal type (ENKTL), and intestinal T-cell lymphoma NOS ( ITCL-NOS). Here we describe a case of surface CD3negative MEITL. A 63-year-old Japanese female had a tumor located in the conglomerated ileum, which formed multiple mass lesions. The resected tissue showed a diffuse infiltration of monomorphic medium- sized lymphocytes with epitheliotropism. Flowcytometry using a fresh specimen of the tumor revealed positivity for CD7, CD8, CD38, and CD56, but not surface CD3. On immunohistochemistry, the tumor showed positivity for cytoplasmic CD3, CD8, CD56, TIA- 1, Granzyme B, and perforin. EBER with in situ hybridization was negative. Moreover, H3K36me3, which is negative in MEITL with SETD2-mutation, was positive. This is an important case of MEITL due to its oncogenesis.

引用

页码：169 / 174

页数：6

共 26 条

[11] Increasing incidence rates, distribution and histological characteristics of primary gastrointestinal non-Hodgkin lymphoma in a North American population
Howell, J. M.
Auer-Grzesiak, I.
Zhang, J.
Andrews, C. N.
Stewart, D.
Urbanski, S. J.
[J]. CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2012, 26 (07) : 452 - 456
[12] Extranodal natural killer/T-cell lymphoma, nasal type in Taiwan: a relatively higher frequency of T-cell lineage and poor survival for extranasal tumors
Jhuang, Jie-Yang
Chang, Sheng-Tsung
Weng, Shih-Feng
Pan, Shien-Tung
Chu, Pei-Yi
Hsieh, Pin-Pen
Wei, Chih-Hsin
Chou, Shih-Cheng
Koo, Chiew-Loon
Chen, Chih-Jung
Hsu, Jeng-Dong
Chuang, Shih-Sung
[J]. HUMAN PATHOLOGY, 2015, 46 (02) : 313 - 321
[13] Enteropathy-Associated T-Cell Lymphoma Type II Complicated by Autoimmune Hemolytic Anemia
Kato, Aiko
Takiuchi, Yoko
Aoki, Kazunari
Ono, Yuichiro
Arima, Hiroshi
Nagano, Seiji
Tabata, Sumie
Yanagita, Soshi
Matsushita, Akiko
Maruoka, Hayato
Wada, Masaya
Imai, Yukihiro
Ishikawa, Takayuki
Takahashi, Takayuki
[J]. JOURNAL OF CLINICAL AND EXPERIMENTAL HEMATOPATHOLOGY, 2011, 51 (02) : 119 - 123
[14] Flow Cytometric Immunophenotyping Is Sensitive for the Early Diagnosis of De Novo Aggressive Natural Killer Cell Leukemia (ANKL): A Multicenter Retrospective Analysis
Li, Yi
Wei, Jia
Mao, Xia
Gao, Qingping
Liu, Longlong
Cheng, Ping
Liu, Limei
Zhang, Xinhua
Zhang, Ke
Wang, Jin
Zhu, Li
Zhou, Jianfeng
Zhang, Yicheng
Meng, Li
Sun, Hanying
Li, Dengju
Huang, Mei
Huang, Wei
Deng, Jinniu
Zhang, Donghua
[J]. PLOS ONE, 2016, 11 (08):
[15] A CD8+ NK cell transcriptomic signature associated with clinical outcome in relapsing remitting multiple sclerosis
McKinney, Eoin F.
Cuthbertson, Iona
Harris, Kristina M.
Smilek, Dawn E.
Connor, Christopher
Manferrari, Giulia
Carr, Edward J.
Zamvil, Scott S.
Smith, Kenneth G. C.
[J]. NATURE COMMUNICATIONS, 2021, 12 (01)
[16] JAK-STAT and G-protein-coupled receptor signaling pathways are frequently altered in epitheliotropic intestinal T-cell lymphoma
Nairismagi, M-L
Tan, J.
Lim, J. Q.
Nagarajan, S.
Ng, C. C. Y.
Rajasegaran, V.
Huang, D.
Lim, W. K.
Laurensia, Y.
Wijaya, G. C.
Li, Z. M.
Cutcutache, I.
Pang, W. L.
Thangaraju, S.
Ha, J.
Khoo, L. P.
Chin, S. T.
Dey, S.
Poore, G.
Tan, L. H. C.
Koh, H. K. M.
Sabai, K.
Rao, H-L
Chuah, K. L.
Ho, Y-H
Ng, S-B
Chuang, S-S
Zhang, F.
Liu, Y-H
Pongpruttipan, T.
Ko, Y. H.
Cheah, P-L
Karim, N.
Chng, W-J
Tang, T.
Tao, M.
Tay, K.
Farid, M.
Quek, R.
Rozen, S. G.
Tan, P.
Teh, B. T.
Lim, S. T.
Tan, S-Y
Ong, C. K.
[J]. LEUKEMIA, 2016, 30 (06) : 1311 - 1319
[17] Gastrointestinal non-Hodgkin lymphomas
Olszewska-Szopa, Magdalena
Wrobel, Tomasz
[J]. ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE, 2019, 28 (08): : 1119 - 1124
[18] Type II enteropathy-associated T-cell lymphoma features a unique genomic profile with highly recurrent SETD2 alterations
Roberti, Annalisa
Dobay, Maria Pamela
Bisig, Bettina
Vallois, David
Boechat, Cloe
Lanitis, Evripidis
Bouchindhomme, Brigitte
Parrens, Marie-Cecile
Bossard, Celine
Quintanilla-Martinez, Leticia
Missiaglia, Edoardo
Gaulard, Philippe
de Leval, Laurence
[J]. NATURE COMMUNICATIONS, 2016, 7
[19] Diagnostic approach to T- and NK-cell lymphoproliferative disorders in the gastrointestinal tract
Susan, Swee-Shan Hue
Ng, Siok-Bian
Wang, Shi
Tan, Soo-Yong
[J]. SEMINARS IN DIAGNOSTIC PATHOLOGY, 2021, 38 (04) : 21 - 30
[20] Type II EATL (epitheliotropic intestinal T-cell lymphoma): a neoplasm of intra-epithelial T-cells with predominant CD8αα phenotype
Tan, S-Y
Chuang, S-S
Tang, T.
Tan, L.
Ko, Y-H
Chuah, K-L
Ng, S-B
Chng, W-J
Gatter, K.
Loong, F.
Liu, Y-H
Hosking, P.
Cheah, P-L
Teh, B-T
Tay, K.
Koh, M.
Lim, S-T
[J]. LEUKEMIA, 2013, 27 (08) : 1688 - 1696

← 1 2 3 →