Return to youth with Sox17

被引：6
作者：
Chhabra, Akanksha [1 ,2 ]
Mikkola, Hanna K. A. [1 ,2 ,3 ,4 ,5 ]
机构：
[1] Univ Calif Los Angeles, Inst Mol Biol, Los Angeles, CA 90095 USA
[2] Univ Calif Los Angeles, Dept Mol Cell & Dev Biol, Los Angeles, CA 90095 USA
[3] Univ Calif Los Angeles, Dept Microbiol Immunol & Mol Genet, Los Angeles, CA 90095 USA
[4] Univ Calif Los Angeles, Eli & Edythe Broad Ctr Regenerat Med & Stem Cell, Los Angeles, CA 90095 USA
[5] Univ Calif Los Angeles, Jonsson Comprehens Canc Ctr, Los Angeles, CA 90095 USA
来源：
GENES & DEVELOPMENT | 2011年 / 25卷 / 15期
关键词：
Sox17; fetal; hematopoietic stem cell; self-renewal; HEMATOPOIETIC STEM-CELLS; DIRECT CONVERSION; GENE-EXPRESSION; CRE RECOMBINASE; DEFINED FACTORS; SELF-RENEWAL; PROLIFERATION; FIBROBLASTS; GENERATION; LEUKEMIA;
D O I：
10.1101/gad.17328611
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Maturation of hematopoietic stem cells (HSCs) from fetal to adult state and differentiation to progenitors are thought to follow a one-way street. In this issue of Genes & Development, He and colleagues (pp. 1613-1627) show that overexpression of Sox17 can convert adult multi-potential progenitors to self-renewing HSCs that possess fetal properties. These findings challenge the irreversibility of hematopoietic development, and open up new perspectives to understand the different forms of HSC self-renewal at distinct stages of ontogeny and during transformation.
引用
收藏
页码：1557 / 1562
页数：6
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