Origami with ABC Triblock Terpolymers Based on Glycopolymers: Creation of Virus-Like Morphologies

被引：63
作者：
Dag, Aydan [1 ,2 ,3 ]
Zhao, Jiacheng [1 ,2 ]
Stenzel, Martina H. [1 ,2 ]
机构：
[1] Univ New S Wales, Ctr Adv Macromol Design, Sch Chem, Sydney, NSW 2052, Australia
[2] Univ New S Wales, Sch Chem Engn, Sydney, NSW 2052, Australia
[3] Bezmialem Vakif Univ, Dept Pharmaceut Chem, Fac Pharm, TR-34093 Istanbul, Turkey
来源：
ACS MACRO LETTERS | 2015年 / 4卷 / 05期
基金：
澳大利亚研究理事会;
关键词：
COPOLYMER; POLYMERIZATION; RECEPTORS; MICELLES; VESICLES; CLICK;
D O I：
10.1021/acsmacrolett.5b00163
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
Morphologies, that resemble viruses, were created using a single ABC triblock terpolymer poly(2-acryloylethyl-alpha-D-mannopyranoside)-b-poly(n-butyl acrylate)-b-poly(4-vinylpyridine) (PAcManA(70)-b-PBA(369)-b-PVP370). Morphologies ranging from flower-like micelles, cylindrical micelles, raspberry-like morphologies to nanocaterpillars were obtained by adjusting the pH value during the self-assembly process. The resulting nanoparticles had an abundance of mannose on the surface, which were recognized by the mannose receptors of RAW264.7, a macrophage cell line that can be used as a model for virus entry.
引用
收藏
页码：579 / 583
页数：5
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