Novel membrane-localizing TEMPO derivatives for measurement of cellular oxidative stress at the cell membrane

被引：11

作者：

Ban, Shizuka ^{[1
]}

Nakagawa, Hidehiko ^{[1
]}

Suzuki, Takayoshi ^{[1
]}

Miyata, Naoki ^{[1
]}

机构：

[1] Nagoya City Univ, Grad Sch Pharmaceut Sci, Mizuho Ku, Nagoya, Aichi 4678603, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 05期

关键词：

fluorescein; redox; electron spin resonance; reactive oxygen species; superoxide; inflammation;

D O I：

10.1016/j.bmcl.2006.11.040

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Oxidative stress affecting lipid membranes is considered to be closely related to cardiovascular disease and brain ischernia. In this study, we designed and synthesized membrane-localizing TEMPO derivatives and demonstrated that one of these synthesized probes, compound 1, localized and detected oxidative stress in the cell membrane in an endotoxic model of a mouse macrophage-like cell line. Compound I is therefore a potentially useful probe for evaluating oxidative. stress at the cell membrane. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：1451 / 1454

页数：4

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