Novel membrane-localizing TEMPO derivatives for measurement of cellular oxidative stress at the cell membrane

被引：11
作者：
Ban, Shizuka [1 ]
Nakagawa, Hidehiko [1 ]
Suzuki, Takayoshi [1 ]
Miyata, Naoki [1 ]
机构：
[1] Nagoya City Univ, Grad Sch Pharmaceut Sci, Mizuho Ku, Nagoya, Aichi 4678603, Japan
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 05期
关键词：
fluorescein; redox; electron spin resonance; reactive oxygen species; superoxide; inflammation;
D O I：
10.1016/j.bmcl.2006.11.040
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Oxidative stress affecting lipid membranes is considered to be closely related to cardiovascular disease and brain ischernia. In this study, we designed and synthesized membrane-localizing TEMPO derivatives and demonstrated that one of these synthesized probes, compound 1, localized and detected oxidative stress in the cell membrane in an endotoxic model of a mouse macrophage-like cell line. Compound I is therefore a potentially useful probe for evaluating oxidative. stress at the cell membrane. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1451 / 1454
页数：4
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