Molecular interactions of all possible regioisomers of synthetic myo-inositol phosphates with inositol 1,4,5-trisphosphate 3-kinase

被引：11
作者：
Choi, G
Chang, YT
Chung, SK
Choi, KY
机构：
[1] POHANG UNIV SCI & TECHNOL,DEPT LIFE SCI,POHANG 790784,SOUTH KOREA
[2] POHANG UNIV SCI & TECHNOL,DEPT CHEM,POHANG 790784,SOUTH KOREA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 21期
基金：
新加坡国家研究基金会;
关键词：
D O I：
10.1016/S0960-894X(97)10060-9
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Inositol 1,4,5-trisphosphate 3-kinase (IP3K) catalyzes the ATP-dependent phosphorylation of inositol 1,4,5-trisphosphate [Ins(1,4,5)P-3] generating inositol 1,3,4,5-tetrakisphosphate [Ins(1,3,4,5)P-4]. The inhibitory effects of all possible 38 regioisomers of inositol phosphates [InsPn] on the IP3K activity have been examined. The correlations between inhibitory potencies and their structural features allowed the assessment of the environment in the active site of IP3K, thus resulting in a proposed binding site model. (C) 1997 Elsevier Science Ltd.
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收藏
页码：2709 / 2714
页数：6
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