Risk stratification for invasive fungal infections in patients with hematological malignancies: SEIFEM recommendations

被引：117

作者：

Pagano, Livio ^{[1
]}

Busca, Alessandro ^{[19
]}

Candoni, Anna ^{[20
]}

Cattaneo, Chiara ^{[2
]}

Cesaro, Simone ^{[3
]}

Fanci, Rosa ^{[21
,22
]}

Nadali, Gianpaolo ^{[4
]}

Potenza, Leonardo ^{[23
]}

Russo, Domenico ^{[5
,6
]}

Tumbarello, Mario ^{[24
]}

Nosari, Annamaria ^{[25
,26
]}

Aversa, Franco ^{[7
]}

Lessi, Federica

Criscuolo, Marianna ^{[1
]}

Farina, Francesca ^{[9
]}

Tisi, Maria Chiara ^{[1
]}

Turri, Gloria ^{[4
]}

Barone, Angelica ^{[10
]}

Spolzino, Angelica ^{[7
]}

Del Principe, Maria Ilaria ^{[11
]}

Quinto, Angela Maria ^{[8
]}

Di Blasi, Roberta ^{[1
]}

Maracci, Laura ^{[12
]}

Nabergoj, Mitja

Cambo, Benedetta ^{[7
]}

Pegoraro, Anna ^{[3
]}

Marchesi, Francesco ^{[13
]}

Pascale, Silvia ^{[14
]}

Passi, Angela ^{[2
]}

Carlisi, Melania ^{[15
]}

Polverelli, Nicola ^{[5
,6
,16
]}

Beggia, Barbara ^{[17
]}

Rambaldi, Benedetta

Prezioso, Lucia ^{[7
]}

Sanna, Marco ^{[18
]}

机构：

[1] Univ Cattolica S Cuore, Ist Ematol, Rome, Italy

[2] Spedali Civil Brescia, Ematol, Brescia, Italy

[3] Azienda Osped Univ Integrata, Oncoematol Pediat, Verona, Italy

[4] Azienda Osped Univ Integrata Verona, Unita Operat Complessa Ematol, Verona, Italy

[5] Univ Brescia, Dipartimento Sci Clin & Sperimentali, Unita Malattie Sangue & Trapianto Midollo Osseo, Cattedra Ematol, Brescia, Italy

[6] ASST Spedali Civili, Brescia, Italy

[7] Univ Parma, Dept Clin & Expt Med, Hematol & BMT Unit, Parma, Italy

[8] Azienda Osped Padova, Unita Operat Ematol, Dipartimento Med, Padua, Italy

[9] Univ Milano Bicocca, ASST Monza, Osped San Gerardo, Clin Ematol, Milan, Italy

[10] Azienda Osped Univ, Pediat & Oncoematol, Parma, Italy

[11] Univ Roma Tor Vergata, Dipartimento Biomed & Prevenz, Cattedra Ematol, Rome, Italy

[12] Azienda Osped Univ, Osped Riunti Ancona, Clin Ematol, Ancona, Italy

[13] Regina Elena Natl Canc Inst Rome, Hematol & Stem Cell Transplant Unit, Rome, Italy

[14] Osped Civile Spirito Santo Pescara, Dipartimento Ematol Med Trasfus & Biotecnol, UO Ematol Clin, Pescara, Italy

[15] Univ Palermo, Dipartimento Med Interna & Specialist, Cattedra UO Ematol Con Trapianto, Palermo, Italy

[16] St Orsola Malpighi Univ Hosp Bologna, Dept Expt Diagnost & Specialty Med DIMES, Inst Hematol & Clin Oncol L&A Seragnoli, Bologna, Italy

[17] AO San Giovanni Addolorata, Div Ematol, Rome, Italy

[18] Univ Cagliari, Div Ematol, Cagliari, Italy

[19] AOU Citta Salute & Sci, Stem Cell Transplant Ctr, Turin, Italy

[20] Azienda Osped Univ Santa Maria Misericordia, Clin Ematol, Udine, Italy

[21] Azienda Osped Univ Careggi, Unita Funz Ematol, Florence, Italy

[22] Univ Florence, Florence, Italy

[23] Univ Modena & Reggio Emilia, Dipartimento Sci Med & Chirurg Materno Infantili, UOC Ematol, Modena, Italy

[24] Univ Cattolica S Cuore, Ist Malattie Infett, Rome, Italy

[25] ASST Grande Osped Metropolitano Niguarda, Div Ematol, Milan, Italy

[26] ASST Grande Osped Metropolitano Niguarda, Ctr Trapianti Midollo, Milan, Italy

来源：

BLOOD REVIEWS | 2017年 / 31卷 / 02期

关键词：

Molds; Yeast; Leukemia; Hematopoietic stem cell transplantation; Risk factors; STEM-CELL TRANSPLANTATION; ACUTE LYMPHOBLASTIC-LEUKEMIA; ACUTE MYELOID-LEUKEMIA; DIAGNOSED CHRONIC-PHASE; INTERNATIONAL WORKING GROUP; VERSUS-HOST-DISEASE; ADULT PATIENTS; ASPERGILLUS-FUMIGATUS; BONE-MARROW; ANTIFUNGAL THERAPY;

D O I：

10.1016/j.blre.2016.09.002

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Invasive fungal infections (IFIs) are an important cause of morbidity and mortality in immunocompromised patients. Patients with hematological malignancies undergoing conventional chemotherapy, autologous or allogeneic hematopoietic stem cell transplantation are considered at high risk, and Aspergillus spp. represents the most frequently isolated micro-organisms. In the last years, attention has also been focused on other rare molds (e.g., Zygomycetes, Fusarium spp.) responsible for devastating clinical manifestations. The extensive use of antifungal prophylaxis has reduced the infections from yeasts (e.g., candidemia) even though they are still associated with high mortality rates. This paper analyzes concurrent multiple predisposing factors that could favor the onset of fungal infections. Although neutropenia is common to almost all hematologic patients, other factors play a key role in specific patients, in particular in patients with AML or allogeneic HSCT recipients. Defining those patients at higher risk of IFIs may help to design the most appropriate diagnostic work-up and antifungal strategy. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：17 / 29

页数：13

共 167 条

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