Risk of Peripheral Artery Disease in Patients With Carbon Monoxide Poisoning A Population-Based Retrospective Cohort Study

被引:12
作者
Chen, Yu-Guang [1 ]
Lin, Te-Yu [2 ]
Dai, Ming-Shen [1 ]
Lin, Cheng-Li [3 ]
Hung, Yuan
Huang, Wen-Sheng [4 ]
Kao, Chia-Hung [5 ,6 ,7 ,8 ]
机构
[1] Natl Def Med Ctr, Triserv Gen Hosp, Div Hematol Oncol, Taipei, Taiwan
[2] Natl Def Med Ctr, Triserv Gen Hosp, Div Infect Dis & Trop Med, Div Cardiol,Dept Internal Med, Taipei, Taiwan
[3] China Med Univ, Coll Med, Management Off Hlth Data, Taichung 404, Taiwan
[4] Changhua Christian Hosp, Dept Nucl Med, Changhua, Taiwan
[5] China Med Univ, Grad Inst Clin Med Sci, Coll Med, 2 Yuh Der Rd, Taichung 404, Taiwan
[6] China Med Univ, Sch Med, Coll Med, Taichung 404, Taiwan
[7] China Med Univ Hosp, Dept Nucl Med, Taichung, Taiwan
[8] China Med Univ Hosp, PET Ctr, Taichung, Taiwan
关键词
OXIDATIVE STRESS; PATHOPHYSIOLOGY; ATHEROSCLEROSIS; NEUROPATHOLOGY; INCREASES; TOXICITY;
D O I
10.1097/MD.0000000000001608
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Carbon monoxide (CO) poisoning can cause several life-threatening complications, particularly in cardiovascular and neurological systems. However, no studies have been performed to investigate the association between peripheral artery disease (PAD) and CO poisoning. We constructed a population-based retrospective cohort study to clarify the risks between PAD and CO poisoning.This population-based cohort study involved analyzing data from 1998 to 2010 obtained from the Taiwanese National Health Insurance Research Database, with a follow-up period extending to the end of 2011. We identified patients with CO poisoning and selected a comparison cohort that was frequency matched according to age, sex, and year of diagnosis of CO poisoning at a ratio of 1 patient to 4 control patients. We analyzed the risks for patients with CO poisoning and PAD by using Cox proportional hazards regression models.In this study, 9046 patients with CO poisoning and 36,183 controls were included. The overall risks for developing PAD were 1.85-fold in the patients with CO poisoning compared with the comparison cohort after adjusting for age, sex, and comorbidities.Our long-term cohort study results showed a higher risk for PAD development among patients with CO poisoning.
引用
收藏
页数:6
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