Thalamo-Striatal T2-Weighted Hyperintensities (Unidentified Bright Objects) Correlate With Cognitive Impairments in Neurofibromatosis Type 1 During Childhood

被引：31

作者：

Chabernaud, Camille ^{[1
,2
]}

Sirinelli, Dominique ^{[3
]}

Barbier, Charlotte ^{[3
,4
]}

Cottier, Jean-Philippe ^{[4
]}

Sembely, Catherine ^{[3
]}

Giraudeau, Bruno ^{[5
]}

Deseille-Turlotte, Geraldine ^{[1
,2
]}

Lorette, Gerard ^{[1
,2
,6
]}

Barthez, Marie-Anne ^{[1
,2
]}

Castelnau, Pierre ^{[1
,2
,7
]}

机构：

[1] Hop Clocheville, Pediat Neurol Unit, Tours, France

[2] Hop Clocheville, Reference Ctr Language & Learning Disorders, Tours, France

[3] Hop Clocheville, Pediat Radiol Unit, Tours, France

[4] Bretonneau Hosp, Neuroradiol Unit, Tours, France

[5] INSERM, CIC 202, Tours, France

[6] CHRU Tours, Hop Trousseau, Dermatol Unit, Tours, France

[7] INSERM, U930, Tours, France

来源：

DEVELOPMENTAL NEUROPSYCHOLOGY | 2009年 / 34卷 / 06期

关键词：

HIGH-SIGNAL-INTENSITY; BASAL GANGLIA; LEARNING-DISABILITIES; CHILDREN; MRI; DEFICITS; PROFILE;

D O I：

10.1080/87565640903265137

中图分类号：

B844 [发展心理学（人类心理学）];

学科分类号：

040202 ;

摘要：

Learning disabilities represent the main childhood complication in neurofibromatosis type 1 (NF1). Patients frequently exhibit T2-weighted hyperintensities called unidentified bright objects (UBOs) on brain magnetic resonance imaging (MRI), with unclear relationship to such cognitive disabilities. This study aimed to determine whether thalamo-striatal UBOs correlate with cognitive disturbances. Thirty-seven NF1 children were studied: 24 with UBOs (18 of which were thalamo-striatal UBOs), and 13 without UBOs. NF1 subjects carrying thalamo-striatal UBOs had significantly lower IQs and visuospatial performances than those without UBOs in this location. These results suggest that UBOs may contribute to NF1 cognitive impairments through thalamo-cortical dysfunction.

引用

页码：736 / 748

页数：13

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