Different brands of intravenous immunoglobulin for primary immunodeficiencies: how to choose the best option for the patient?

被引：25

作者：

Abolhassani, Hasssan ^{[1
,2
]}

Asgardoon, Mohammad Hossein ^{[1
]}

Rezaei, Nima ^{[1
,3
,4
]}

Hammarstrom, Lennart ^{[2
]}

Aghamohammadi, Asghar ^{[1
]}

机构：

[1] Univ Tehran Med Sci, Childrens Med Ctr, Pediat Ctr Excellence, Res Ctr Immunodeficiencies, Tehran, Iran

[2] Karolinska Univ, Huddinge Hosp, Karolinska Inst, Dept Lab Med,Div Clin Immunol, Stockholm, Sweden

[3] Univ Tehran Med Sci, Sch Med, Dept Immunol, Tehran, Iran

[4] Univ Tehran Med Sci, Mol Immunol Res Ctr, Tehran, Iran

来源：

EXPERT REVIEW OF CLINICAL IMMUNOLOGY | 2015年 / 11卷 / 11期

关键词：

formulations; intravenous immunoglobulin; primary immunodeficiency disease; risk factors; COMMON VARIABLE IMMUNODEFICIENCY; PRIMARY ANTIBODY DEFICIENCIES; PRIMARY IMMUNE-DEFICIENCY; REPLACEMENT THERAPY; GAMMA-GLOBULIN; SUBCUTANEOUS IMMUNOGLOBULIN; PRIMARY HYPOGAMMAGLOBULINEMIA; IMMUNOLOGICAL FEATURES; IRANIAN PATIENTS; ADVERSE EVENTS;

D O I：

10.1586/1744666X.2015.1079485

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Immunoglobulin (IG) replacement therapy has served as lifesaving treatment in primary immunodeficiency diseases (PID) for more than six decades. Approximately 70% of patients with PID require IG replacement to maintain their health during the course of disease. It is estimated that about one-third of IG products is used for replacement therapy in these patients. On the other hand, the introduction of newer IG preparations is continuing to improve and extend the quality of life in PID patients. Because of the options available including concentrations, formulations, osmolality, product stabilizers, sodium concentration, anti-infective activity, IgA content and pH, it is important to match the PID patient's complications with potential side effects associated with the composition of a particular IG product. The purpose of this review is to present the clinical differences of intravenous IG among the various preparations regarding PID patients.

引用

页码：1229 / 1243

页数：15

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