Dyskinesia is Closely Associated with Synchronization of Theta Oscillatory Activity Between the Substantia Nigra Pars Reticulata and Motor Cortex in the Off L-dopa State in Rats

被引:9
作者
Chen, Jiazhi [1 ]
Wang, Qiang [1 ,3 ]
Li, Nanxiang [1 ]
Huang, Shujie [1 ]
Li, Min [1 ]
Cai, Junbin [1 ]
Wang, Yuzheng [2 ]
Wen, Huantao [1 ]
Lv, Siyuan [1 ]
Wang, Ning [2 ]
Wang, Jinyan [2 ]
Luo, Fei [2 ]
Zhang, Wangming [1 ]
机构
[1] Southern Med Univ, Zhujiang Hosp, Dept Neurosurg,Guangdong Prov Key Lab Brain Funct, Engn Technol Res Ctr,Natl Key Clin Specialty,Mini, Guangzhou 510282, Peoples R China
[2] Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
[3] Charite Univ Med Berlin, Dept Neurol, Movement Disorders & Neuromodulat Unit, D-10117 Berlin, Germany
基金
中国国家自然科学基金;
关键词
Parkinson's disease; Dyskinesia; Substantia nigra pars reticulata; Primary motor cortex; Synchronization;
D O I
10.1007/s12264-020-00606-3
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Excessive theta (theta) frequency oscillation and synchronization in the basal ganglia (BG) has been reported in elderly parkinsonian patients and animal models of levodopa (L-dopa)-induced dyskinesia (LID), particularly the theta oscillation recorded during periods when L-dopa is withdrawn (the off L-dopa state). To gain insight into processes underlying this activity, we explored the relationship between primary motor cortex (M1) oscillatory activity and BG output in LID. We recorded local field potentials in the substantia nigra pars reticulata (SNr) and M1 of awake, inattentive resting rats before and after L-dopa priming in Sham control, Parkinson disease model, and LID model groups. We found that chronic L-dopa increased theta synchronization and information flow between the SNr and M1 in off L-dopa state LID rats, with a SNr-to-M1 flow directionality. Compared with the on state, theta oscillational activity (theta synchronization and information flow) during the off state were more closely associated with abnormal involuntary movements. Our findings indicate that theta oscillation in M1 may be consequent to abnormal synchronous discharges in the BG and support the notion that M1 theta oscillation may participate in the induction of dyskinesia.
引用
收藏
页码:323 / 338
页数:16
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