Supervised Disulfiram in Relapse Prevention in Alcohol-Dependent Patients Suffering From Comorbid Borderline Personality Disorder-A Case Series

被引:10
作者
Mutschler, Jochen [1 ,2 ]
Grosshans, Martin [1 ]
Koopmann, Anne [1 ]
Hermann, Derik [1 ]
Diehl, Alexander [3 ]
Mann, Karl [1 ]
Kiefer, Falk [1 ]
机构
[1] Heidelberg Univ, Cent Inst Mental Hlth, Dept Addict Behav & Addict Med, D-68159 Mannheim, Germany
[2] Psychiat Univ Hosp Zurich, Dept Gen & Social Psychiat, CH-8021 Zurich, Switzerland
[3] Klinikum Braunschweig, Dept Psychiat, Braunschweig, Germany
来源
ALCOHOL AND ALCOHOLISM | 2010年 / 45卷 / 02期
关键词
PHARMACOTHERAPY; ACAMPROSATE; IMPACT; PREDICTORS; ADDICTION; DRINKING; OUTCOMES; TRIAL;
D O I
10.1093/alcalc/agq001
中图分类号
R194 [卫生标准、卫生检查、医药管理];
学科分类号
摘要
Methods: Case history study of patients diagnosed with BPD, prescribed disulfiram in a dose of 1.5-2.5 g/week, supervised by a physician in up to three brief contacts per week. Results: Two out of eight patients remained completely abstinent during the supervised disulfiram therapy over a mean period of 9.25 months. Adherence to treatment was 18.44 +/- 21.78 months. The first relapse occurred after 1.38 +/- 1.41 months. The cumulated time of abstinence was 16.88 +/- 20.48 months. The overall tolerability was considered to be high; dizziness and fatigue appeared in all patients at the beginning of the therapy but did not persist. No serious adverse events or ethanol-disulfiram interactions were observed. No suicidal behaviour was reported. Conclusions: Although case observations should be interpreted with caution, supervised disulfiram seems to deserve further investigation in patients with comorbid BPD, for whom it appears to help prevent alcoholic relapse.
引用
收藏
页码:146 / 150
页数:5
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