SULFONIUM-ION GLYCOSIDASE INHIBITORS ISOLATED FROM Salacia SPECIES USED IN TRADITIONAL MEDICINE, AND RELATED COMPOUNDS

被引：20

作者：

Mohan, Sankar ^{[1
]}

Pinto, B. Mario ^{[1
]}

机构：

[1] Simon Fraser Univ, Dept Chem, Burnaby, BC V5A 1S6, Canada

来源：

COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS | 2009年 / 74卷 / 7-8期

基金：

加拿大自然科学与工程研究理事会;

关键词：

Glycosidase inhibitors; Carbohydrates; Thiasugars; Sulfonium sulfates; Salacinol; Salaprinol; Natural products; OCCURRING GLUCOSIDASE INHIBITOR; HUMAN MALTASE GLUCOAMYLASE; CHAIN-EXTENDED HOMOLOGS; DIABETIC FATTY RATS; AYURVEDIC MEDICINE; SULFATE STRUCTURE; OBLONGA ROOT; SIDE-CHAIN; BIOLOGICAL EVALUATION; NATURAL-PRODUCTS;

D O I：

10.1135/cccc2009024

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel class of naturally-occurring glycosidase inhibitors, having sulfonium sulfate structures, has been isolated as bioactive components from Indian plants, belonging to the Salacia genus in the family Celastraceae, and used in Ayurvedic medicine for the treatment of type-2 diabetes. Thus far, five such sulfonium salts, namely, salacinol, kotalanol, salaprinol, ponkoranol and de-O-sulfonated kotalanol, have been isolated from this plant species. These structurally unique zwitterionic glycosidase inhibitors have received much attention due to their therapeutic potential in the treatment of type-2 diabetes. We recently reported a review article which focused mainly on salacinol and related analogues. The present review presents an update on the remaining four compounds from this class of glycosidase inhibitors, with respect to their isolation, glucosidase inhibitory activities, and synthesis. In addition, progress towards the stereochemical structure elucidation of kotalanol, through synthesis of analogues, is described. Review with 42 references.

引用

页码：1117 / 1136

页数：20

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