IDN1 and IDN2 are required for de novo DNA methylation in Arabidopsis thaliana

被引：84
作者：
Ausin, Israel [1 ]
Mockler, Todd C. [2 ,3 ]
Chory, Joanne [4 ,5 ]
Jacobsen, Steven E. [1 ,6 ]
机构：
[1] Univ Calif Los Angeles, Dept Mol Cell & Dev Biol, Los Angeles, CA 90024 USA
[2] Oregon State Univ, Dept Bot & Plant Pathol, Corvallis, OR 97331 USA
[3] Oregon State Univ, Ctr Genome Res & Biocomp, Corvallis, OR 97331 USA
[4] Salk Inst Biol Studies, Plant Biol Lab, La Jolla, CA 92037 USA
[5] Howard Hughes Med Inst, La Jolla, CA USA
[6] Univ Calif Los Angeles, Howard Hughes Med Inst, Los Angeles, CA 90024 USA
来源：
NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2009年 / 16卷 / 12期
基金：
美国国家卫生研究院;
关键词：
PROCESSING CENTER; GENES; PROTEIN; DOMAIN; PLANTS; DRM;
D O I：
10.1038/nsmb.1690
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
DNA methylation is an epigenetic mark affecting genes and transposons. Screening for mutants that fail to establish DNA methylation yielded two we termed "involved in de novo" (idn) 1 and 2. IDN1 encodes DMS3, an SMC-related protein, and IDN2 encodes a previously unknown double-stranded RNA-binding protein with homology to SGS3. IDN1 and IDN2 control de novo methylation and small interfering RNA (siRNA)-mediated maintenance methylation and are components of the RNA-directed DNA methylation pathway.
引用
收藏
页码：1325 / 1327
页数：3
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