Poly(ADP-ribose): the structure and the synthesis

被引：0
|
作者：
Zhao, Lang [1 ]
Wu, Jun J. [1 ]
Li, Yan M. [1 ,2 ,3 ]
机构：
[1] Tsinghua Univ, Dept Chem, Key Lab Bioorgan Phosphorus Chem & Chem Biol, Beijing 100084, Peoples R China
[2] Beijing Inst Brain Disorders, Beijing 100069, Peoples R China
[3] Tsinghua Univ, Ctr Synthet & Syst Biol, Beijing 100084, Peoples R China
来源：
ARKIVOC | 2021年
基金：
国家重点研发计划; 中国国家自然科学基金;
关键词：
Poly(ADP-ribose); post-translational modification; poly(ADP-ribosyl)ation; structure; synthesis; POLY(ADENOSINE DIPHOSPHATE RIBOSE); ADP-RIBOSYLATION; DISACCHARIDE NUCLEOSIDES; NAD(+) ANALOGS; NONCOVALENT INTERACTION; STRUCTURE ELUCIDATION; CHEMICAL-SYNTHESIS; DNA; PROTEINS; BINDING;
D O I：
10.24820/ark.5550190.p011.311
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Poly(ADP-ribose) belongs to a momentous post-translational modification of eukaryotic nuclear protein. Protein poly(ADP-ribosyl)ation mediates numerous cell signalings and is related to some diseases. Poly(ADPribose) is currently available through enzymatic or chemical synthesis. Herein, we summarize the structure characteristics and recent developments in the synthesis of poly(ADP-ribose) from a chemical point of view. [GRAPHICS] .
引用
收藏
页码：65 / 88
页数：24
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