Poly(ADP-ribose): the structure and the synthesis

被引：0
|
作者：
Zhao, Lang [1 ]
Wu, Jun J. [1 ]
Li, Yan M. [1 ,2 ,3 ]
机构：
[1] Tsinghua Univ, Dept Chem, Key Lab Bioorgan Phosphorus Chem & Chem Biol, Beijing 100084, Peoples R China
[2] Beijing Inst Brain Disorders, Beijing 100069, Peoples R China
[3] Tsinghua Univ, Ctr Synthet & Syst Biol, Beijing 100084, Peoples R China
来源：
ARKIVOC | 2021年
基金：
国家重点研发计划; 中国国家自然科学基金;
关键词：
Poly(ADP-ribose); post-translational modification; poly(ADP-ribosyl)ation; structure; synthesis; POLY(ADENOSINE DIPHOSPHATE RIBOSE); ADP-RIBOSYLATION; DISACCHARIDE NUCLEOSIDES; NAD(+) ANALOGS; NONCOVALENT INTERACTION; STRUCTURE ELUCIDATION; CHEMICAL-SYNTHESIS; DNA; PROTEINS; BINDING;
D O I：
10.24820/ark.5550190.p011.311
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Poly(ADP-ribose) belongs to a momentous post-translational modification of eukaryotic nuclear protein. Protein poly(ADP-ribosyl)ation mediates numerous cell signalings and is related to some diseases. Poly(ADPribose) is currently available through enzymatic or chemical synthesis. Herein, we summarize the structure characteristics and recent developments in the synthesis of poly(ADP-ribose) from a chemical point of view. [GRAPHICS] .
引用
收藏
页码：65 / 88
页数：24
相关论文
共 50 条
  • [1] Synthesis of Dimeric ADP-Ribose and Its Structure with Human Poly(ADP-ribose) Glycohydrolase
    Lambrecht, Michael J.
    Brichacek, Matthew
    Barkauskaite, Eva
    Ariza, Antonio
    Ahel, Ivan
    Hergenrother, Paul J.
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2015, 137 (10) : 3558 - 3564
  • [2] STRUCTURE OF POLY(ADP-RIBOSE)
    MIWA, M
    SUGIMURA, T
    METHODS IN ENZYMOLOGY, 1984, 106 : 441 - 450
  • [3] STRUCTURE AND BIOSYNTHESIS OF POLY(ADP-RIBOSE)
    DOLY, J
    CHAMBON, P
    MANDEL, P
    HOPPE-SEYLERS ZEITSCHRIFT FUR PHYSIOLOGISCHE CHEMIE, 1972, 353 (06): : 843 - &
  • [4] Straightforward Synthesis of the Poly(ADP-ribose) Branched Core Structure
    Hagino, Rui
    Mozaki, Keita
    Komura, Naoko
    Imamura, Akihiro
    Ishida, Hideharu
    Ando, Hiromune
    Tanaka, Hide-Nori
    ACS OMEGA, 2022, 7 (36): : 32795 - 32804
  • [5] POLY ADP-RIBOSE
    不详
    NATURE-NEW BIOLOGY, 1973, 245 (146): : 193 - 195
  • [6] POLY(ADP-RIBOSE)
    SMULSON, M
    SHALL, S
    NATURE, 1976, 263 (5572) : 14 - 14
  • [7] DETERMINATION OF ADP-RIBOSE AND POLY(ADP-RIBOSE) BY A NEW RADIOIMMUNOASSAY
    BREDEHORST, R
    FERRO, AM
    HILZ, H
    EUROPEAN JOURNAL OF BIOCHEMISTRY, 1978, 82 (01): : 115 - 121
  • [8] Importance of poly(ADP-ribose) glycohydrolase in the control of poly(ADP-ribose) metabolism
    Davidovic, L
    Vodenicharov, M
    Affar, EB
    Poirier, GG
    EXPERIMENTAL CELL RESEARCH, 2001, 268 (01) : 7 - 13
  • [9] Poly(etheno ADP-ribose) blocks poly(ADP-ribose) glycohydrolase activity
    Shirato, Masayasu
    Tozawa, Shunichi
    Maeda, Daisuke
    Watanabe, Masatoshi
    Nakagama, Hitoshi
    Masutani, Mitsuko
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2007, 355 (02) : 451 - 456
  • [10] STRUCTURE AND FUNCTION OF POLY(ADP-RIBOSE) POLYMERASE
    DEMURCIA, G
    SCHREIBER, V
    MOLINETE, M
    SAULIER, B
    POCH, O
    MASSON, M
    NIEDERGANG, C
    DEMURCIA, JM
    MOLECULAR AND CELLULAR BIOCHEMISTRY, 1994, 138 (1-2) : 15 - 24
12345