Evolution of oxidative/nitrosative stress biomarkers during an open-field vaccination procedure in sheep: Effect of melatonin

被引：9

作者：

Ramos, Asuncion ^{[1
]}

Laguna, Ines ^{[1
]}

Martin de Lucia, Maria-Luisa ^{[1
]}

Martin-Palomino, Pedro ^{[1
]}

Regodon, Sergio ^{[2
]}

Miguez, Maria-Prado ^{[1
]}

机构：

[1] Univ Extremadura, Dept Anim Hlth, Fac Vet Med, Caceres 10071, Spain

[2] Univ Extremadura, Dept Anim Med, Fac Vet Med, Caceres 10071, Spain

来源：

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY | 2010年 / 133卷 / 01期

关键词：

Immunization; Melatonin; Oxidative stress; Nitric oxide; Sheep; OVINE FOOTROT; DICHELOBACTER-NODOSUS; NITRIC-OXIDE; OXIDATIVE STRESS; FREE-RADICALS; ANTIOXIDANT; LYMPHOCYTES; NITRATE; PROLIFERATION; PARAMETERS;

D O I：

10.1016/j.vetimm.2009.06.016

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Melatonin has been shown to exert immunomodularory properties with broad application in veterinary medicine. In previous work we have described that subcutaneous coadministration of melatonin to seeps vaccinated against two stumps of Al and C strains of Dichelobacter nodosus enhanced both the antibody titer and serum IgG levels to Al and C strains of D. nodosus compared to vaccinated animals not treated with melatonin. Following a similar protocol here we have investigated the effect of a higher dose of melatonin (36 mg/animal) in the improvement of the immune response and in the possible oxidative/nitrosative stress produced during the immunization protocol. Our results show that footrot vaccine application induced nitrosative but not oxidative stress at 42 days post-vaccination, which was neutralized by melatonin administration. On the other hand, melatonin improved the immune response with respect to our previous data increasing the time of permanence of antibodies in serum, opening new perspectives for melatonin as prophylactic drug. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：16 / 24

页数：9

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