The impact of tibolone on cardiovascular system and haemostasis of menopausal women

被引:0
作者
Stachowiak, Grzegorz [1 ]
Pertynski, Tomasz [1 ]
机构
[1] Inst Ctr Zdrowia Matki Polki Lodzi, Klin Ginekol & Chorob Menopauzy, PL-93338 Lodz, Poland
来源
PRZEGLAD MENOPAUZALNY | 2009年 / 8卷 / 04期
关键词
tibolone; menopause; cardiovascular system; coagulation; fibrinolysis; HORMONE REPLACEMENT THERAPY; PLUS MEDROXYPROGESTERONE ACETATE; ISCHEMIC-HEART-DISEASE; C-REACTIVE PROTEIN; POSTMENOPAUSAL WOMEN; VENOUS THROMBOEMBOLISM; MYOCARDIAL-INFARCTION; CONTROLLED TRIAL; RISK; ESTROGEN;
D O I
暂无
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Tibolone - a synthetic steroid with oestrogen, progesterone and androgen activity - influences circulatory system and haemostasis of menopausal women. Its impact on lipid profile, inflammatory parameters, coagulation, fibrinolysis and vascular wall can modify the risk of ischemic heart disease, stroke and deep vein thrombosis. Available date testify clearly that tibolone is a good alternative to oestrogen-progesterone menopausal hormone therapy (MHT).
引用
收藏
页码:179 / 183
页数:5
相关论文
共 30 条
  • [1] Tibolone improves myocardial perfusion in postmenopausal women with ischemic heart disease - An open-label exploratory pilot study
    Campisi, R
    Camilletti, J
    Mele, A
    Erriest, J
    Pedroni, P
    Guiglioni, A
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2006, 47 (03) : 559 - 564
  • [2] Brachial artery responses in menopausal women using tibolone
    Carranza-Lira, Sebastian
    Cuan-Martinez, Juan R.
    Rosales-Ortiz, Sergio
    [J]. INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS, 2008, 101 (01) : 43 - 46
  • [3] Venous endothelial function in postmenopausal women after six months of tibolone therapy
    Ceballos, C
    Ribes, C
    Amado, JA
    de Mier, I
    de Rozas, LS
    Berrazueta, JR
    [J]. MATURITAS, 2001, 39 (01) : 63 - 70
  • [4] Differential effect of hormone therapy and tibolone on lipids, lipoproteins, and the atherogenic index of plasma
    Christodoulakos, George E.
    Lambrinoudaki, Irene V.
    Economou, Emmanuel V.
    Papadias, Constantinos
    Panoulis, Constantinos P.
    Kouskouni, Evangelia E.
    Vlachou, Sofia A.
    Creatsas, George C.
    [J]. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 2006, 47 (04) : 542 - 548
  • [5] Long-term effects of tibolone on circulating levels of vascular cell adhesion molecules and E-selectin in postmenopausal women
    Cicinelli, Ettore
    Ranieri, Giuseppe
    Maffei, Silvia
    Colafiglio, Giuseppe
    Ria, Roberto
    Bellavia, Marina
    Schonauer, Matteo M.
    [J]. FERTILITY AND STERILITY, 2006, 86 (04) : 899 - 904
  • [6] Clarke SC, 2002, BJOG-INT J OBSTET GY, V109, P1056, DOI 10.1111/j.1471-0528.2002.01544.x
  • [7] The effects of tibolone in older postmenopausal women
    Cummings, Steven R.
    Ettinger, Bruce
    Delmas, Pierre D.
    Kenemans, Peter
    Stathopoulos, Victoria
    Verweij, Pierre
    Mol-Arts, Mirjam
    Kloosterboer, Lenus
    Mosca, Lori
    Christiansen, Claus
    Bilezikian, John
    Kerzberg, Eduardo Mario
    Johnson, Susan
    Zanchetta, Jose
    Grobbee, Diederich E.
    Seifert, Wilfried
    Eastell, Richard
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2008, 359 (07) : 697 - 708
  • [8] Risk of venous thromboembolism in users of hormone replacement therapy
    Daly, E
    Vessey, MP
    Hawkins, MN
    Carson, JL
    Gough, P
    Marsh, S
    [J]. LANCET, 1996, 348 (9033) : 977 - 980
  • [9] Myocardial infarction risk and hormone replacement: Differences between products
    de Vries, CS
    Bromley, SE
    Farmer, RDT
    [J]. MATURITAS, 2006, 53 (03) : 343 - 350
  • [10] Differential effects of conventional and low dose oral hormone therapy (HT), tibolone, and raloxifene on coagulation and fibrinolysis
    Eilertsen, Anette Loken
    Sandvik, Leiv
    Mowinckel, Marie Christine
    Andersen, Trine Opstad
    Qvigstad, Erik
    Sandset, Per Morten
    [J]. THROMBOSIS RESEARCH, 2007, 120 (03) : 371 - 379