Functional image-based radiotherapy planning for non-small cell lung cancer: A simulation study

被引：50
作者：
Bates, Emma L. [1 ]
Bragg, Christopher M. [2 ]
Wild, Jim M. [3 ]
Hatton, Matthew Q. F. [4 ]
Ireland, Rob H. [3 ,4 ]
机构：
[1] Univ Sheffield, Dept Clin Oncol, Weston Pk Hosp, Sheffield Teaching Hosp NHS Trust, Sheffield S10 2SJ, S Yorkshire, England
[2] Weston Pk Hosp, Dept Radiotherapy, Sheffield, S Yorkshire, England
[3] Univ Sheffield, Acad Unit Radiol, Sheffield S10 2SJ, S Yorkshire, England
[4] Univ Sheffield, Acad Unit Clin Oncol, Sheffield S10 2SJ, S Yorkshire, England
来源：
RADIOTHERAPY AND ONCOLOGY | 2009年 / 93卷 / 01期
关键词：
Intensity-modulated radiotherapy; Non-small cell lung cancer; SPECT; Hyperpolarized helium-3 MRI; Radiotherapy treatment planning; INTENSITY-MODULATED RADIOTHERAPY; HYPERPOLARIZED HE-3 MRI; THERAPY ONCOLOGY GROUP; RADIATION-THERAPY; TUMOR-CONTROL; SPECT; IMRT; REGISTRATION; FEASIBILITY; TOXICITY;
D O I：
10.1016/j.radonc.2009.05.018
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background and purpose: To investigate the incorporation of data from single-photon emission computed tomography (SPECT) or hyperpolarized helium-3 magnetic resonance imaging (He-3-MRI) into intensity-modulated radiotherapy (IMRT) planning for non-small cell lung cancer (NSCLC). Material and methods: Seven scenarios were simulated that represent cases of NSCLC with significant functional lung defects. Two independent IMRT plans were produced for each scenario; one to minimise total lung volume receiving >= 20 Gy (V-20), and the other to minimise only the functional lung volume receiving >= 20 Gy (FV20). Dose-volume characteristics and a plan quality index related to planning target volume coverage by the 95% isodose (V-PTV95/FV20) were compared between anatomical and functional plans using the Wilcoxon signed ranks test. Results: Compared to anatomical IMRT plans, functional planning reduced FV20 (median 2.7%, range 0.6-3.5%, p = 0.02), and total lung V-20 (median 1.5%, 0.5-2.7%, p = 0.02), with a small reduction in mean functional lung dose (median 0.4 Gy, 0-0.7 Gy, p = 0.03). There were no significant differences in target volume coverage or organ-at-risk doses. Plan quality index was improved for functional plans (median increase 1.4, range 0-11.8, p = 0.02). Conclusions: Statistically significant reductions in FV20, V-20 and mean functional lung dose are possible when IMRT planning is supplemented by functional information derived from SPECT or He-3-MRI. (C) 2009 Elsevier Ireland Ltd. All rights reserved. Radiotherapy and Oncology 93 (2009) 32-36
引用
收藏
页码：32 / 36
页数：5
相关论文
共 22 条
[1]  
[Anonymous], 2001, Cochrane Database Syst Rev, DOI DOI 10.1002/14651858.CD002935
[2]   Clinical implications of the anisotropic analytical algorithm for IMRT treatment planning and verification [J].
Bragg, Christopher M. ;
Wingate, Katrina ;
Conway, John .
RADIOTHERAPY AND ONCOLOGY, 2008, 86 (02) :276-284
[3]   Response, toxicity, failure patterns, and survival in five radiation therapy oncology group (RTOG) trials of sequential and/or concurrent chemotherapy and radiotherapy for locally advanced non-small-cell carcinoma of the lung [J].
Byhardt, RW ;
Scott, C ;
Sause, WT ;
Emami, B ;
Komaki, R ;
Fisher, B ;
Lee, JS ;
Lawton, C .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1998, 42 (03) :469-478
[4]   The incorporation of SPECT functional lung imaging into inverse radiotherapy planning for non-small cell lung cancer [J].
Christian, JA ;
Partridge, M ;
Nioutsikou, E ;
Cook, G ;
McNair, HA ;
Cronin, B ;
Courbon, F ;
Bedford, JL ;
Brada, M .
RADIOTHERAPY AND ONCOLOGY, 2005, 77 (03) :271-277
[5]   An image acquisition and registration strategy for the fusion of hyperpolarized helium-3 MRI and x-ray CT images of the lung [J].
Ireland, Rob H. ;
Woodhouse, Neil ;
Hoggard, Nigel ;
Swinscoe, James A. ;
Foran, Bernadette H. ;
Hatton, Matthew Q. ;
Wild, Jim M. .
PHYSICS IN MEDICINE AND BIOLOGY, 2008, 53 (21) :6055-6063
[6]   Feasibility of image registration and intensity-modulated radiotherapy planning with hyperpolarized helium-3 magnetic resonance imaging for non-small-cell lung cancer [J].
Ireland, Rob H. ;
Bragg, Chris M. ;
McJury, Mark ;
Woodhouse, Neil ;
Fichele, Stan ;
Van Beek, Edwin J. R. ;
Wild, Jim M. ;
Hatton, Matthew Q. .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2007, 68 (01) :273-281
[7]   Pretreatment prognostic factors in patients with early-stage (I/II) non-small-cell lung cancer treated with hyperfractionated radiation therapy alone [J].
Jeremic, Branislav ;
Milicic, Biljana ;
Dagovic, Aleksandar ;
Acimovic, Ljubisa ;
Milisavljevic, Slobodan .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2006, 65 (04) :1112-1119
[8]   High-dose radiation improved local tumor control and overall survival in patients with inoperable/unresectable non-small-cell lung cancer: Long-term results of a radiation dose escalation study [J].
Kong, FM ;
Ten Haken, RK ;
Schipper, MJ ;
Sullivan, MA ;
Chen, M ;
Lopez, C ;
Kalemkerian, GP ;
Hayman, JA .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2005, 63 (02) :324-333
[9]   A potential to reduce pulmonary toxicity: The use of perfusion SPECT with IMRT for functional lung avoidance in radiotherapy of non-smalt cell lung cancer [J].
Lavrenkov, Konstantin ;
Christian, Judith A. ;
Partridge, Mike ;
Niotsikou, Elena ;
Cook, Gary ;
Parker, Michelle ;
Bedford, James L. ;
Brada, Michael .
RADIOTHERAPY AND ONCOLOGY, 2007, 83 (02) :156-162
[10]   Effective avoidance of a functional spect-perfused lung using intensity modulated radiotherapy (IMRT) for non-small cell lung cancer (NSCLC): An update of a planning study [J].
Lavrenkov, Konstantin ;
Singh, Shalini ;
Christian, Judith A. ;
Partridge, Mike ;
Nioutsikou, Elena ;
Cook, Gary ;
Bedford, James L. ;
Brada, Michael .
RADIOTHERAPY AND ONCOLOGY, 2009, 91 (03) :349-352
123