Post-Treatment Controllers: Role in HIV "Cure" Research

被引：26
作者：
Cockerham, Leslie R. [1 ]
Hatano, Hiroyu [2 ]
Deeks, Steven G. [2 ]
机构：
[1] Med Coll Wisconsin, Div Infect Dis, 9200 W Wisconsin Ave,Suite 5100, Milwaukee, WI 53226 USA
[2] Univ Calif San Francisco, San Francisco Gen Hosp, Div HIV AIDS, 995 Potrero Ave, San Francisco, CA 94110 USA
来源：
CURRENT HIV/AIDS REPORTS | 2016年 / 13卷 / 01期
关键词：
HIV infection; HIV latency; HIV viral rebound; T cell activation; Post-treatment controllers; Antiretroviral therapy; HUMAN-IMMUNODEFICIENCY-VIRUS; CD4(+) T-CELLS; ANTIRETROVIRAL THERAPY; IMMUNE ACTIVATION; RALTEGRAVIR INTENSIFICATION; PRIMARY INFECTION; LATENT RESERVOIR; SIV INFECTION; OPEN-LABEL; B-CELLS;
D O I：
10.1007/s11904-016-0296-x
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Descriptions of individuals who are able to control viral replication in the absence of antiretroviral therapy after receiving short-term therapy early in infection ("post-treatment controllers") has generated excitement and controversy within the field. As with natural or "elite" controllers, these cases provide hope that a long-term remission or "functional cure" might one day be possible. Here, we review what is known and not known about these cases and discuss the immunologic factors that may allow these unique individuals to be maintain viral control and may be important for future curative strategies.
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页码：1 / 9
页数：9
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