Lymph Node Stromal Cells Support Dendritic Cell-Induced Gut-Homing of T Cells

被引：107

作者：

Molenaar, Rosalie ^{[1
]}

Greuter, Mascha ^{[1
]}

van der Marel, Arnold P. J. ^{[1
]}

Roozendaal, Ramon ^{[1
]}

Martin, Stefan F. ^{[2
]}

Edele, Fanny ^{[2
]}

Huehn, Jochen ^{[3
]}

Foerster, Reinhold ^{[4
]}

O'Toole, Tom ^{[1
]}

Jansen, Wendy ^{[1
]}

Eestermans, Inge L. ^{[1
]}

Kraal, Georg ^{[1
]}

Mebius, Reina E. ^{[1
]}

机构：

[1] Vrije Univ Amsterdam, Univ Med Ctr, Dept Mol Cell Biol & Immunol, NL-1007 MB Amsterdam, Netherlands

[2] Univ Med Ctr Freiburg, Allergy Res Grp, Dept Dermatol, Freiburg, Germany

[3] Helmholtz Ctr Infect Res, Braunschweig, Germany

[4] Hannover Med Sch, Inst Immunol, D-3000 Hannover, Germany

来源：

JOURNAL OF IMMUNOLOGY | 2009年 / 183卷 / 10期

关键词：

FIBROBLASTIC RETICULAR CELLS; THYMUS-EXPRESSED CHEMOKINE; RETINOIC-ACID; RECEPTOR PATTERNS; SMALL-INTESTINE; LAMINA PROPRIA; GENERATION; LYMPHOCYTES; TECK; TOLERANCE;

D O I：

10.4049/jimmunol.0900311

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

T cells are imprinted to express tissue-specific homing receptors upon activation in tissue-draining lymph nodes, resulting in their migration to the site of Ag entry. Expression of gut-homing molecules alpha(4)beta(7), and CCR9 is induced by retinoic acid, a vitamin A metabolite produced by retinal dehydrogenases, which are specifically expressed in dendritic cells as well as stromal cells in mucosa-draining lymph nodes. In this study, we demonstrate that mesenteric lymph node stromal cell-derived retinoic acid can directly induce the expression of gut-homing molecules on proliferating T cells, a process strongly enhanced by bone marrow-derived dendritic cells in vitro. Therefore, cooperation of sessile lymph node stromal cells with mobile dendritic cells warrants the imprinting of tissue specific homing receptors on activated T cells. The Journal of Immunology, 2009, 183: 6395-6402.

引用

页码：6395 / 6402

页数：8

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