Lymph Node Stromal Cells Support Dendritic Cell-Induced Gut-Homing of T Cells

被引：107
作者：
Molenaar, Rosalie [1 ]
Greuter, Mascha [1 ]
van der Marel, Arnold P. J. [1 ]
Roozendaal, Ramon [1 ]
Martin, Stefan F. [2 ]
Edele, Fanny [2 ]
Huehn, Jochen [3 ]
Foerster, Reinhold [4 ]
O'Toole, Tom [1 ]
Jansen, Wendy [1 ]
Eestermans, Inge L. [1 ]
Kraal, Georg [1 ]
Mebius, Reina E. [1 ]
机构：
[1] Vrije Univ Amsterdam, Univ Med Ctr, Dept Mol Cell Biol & Immunol, NL-1007 MB Amsterdam, Netherlands
[2] Univ Med Ctr Freiburg, Allergy Res Grp, Dept Dermatol, Freiburg, Germany
[3] Helmholtz Ctr Infect Res, Braunschweig, Germany
[4] Hannover Med Sch, Inst Immunol, D-3000 Hannover, Germany
来源：
JOURNAL OF IMMUNOLOGY | 2009年 / 183卷 / 10期
关键词：
FIBROBLASTIC RETICULAR CELLS; THYMUS-EXPRESSED CHEMOKINE; RETINOIC-ACID; RECEPTOR PATTERNS; SMALL-INTESTINE; LAMINA PROPRIA; GENERATION; LYMPHOCYTES; TECK; TOLERANCE;
D O I：
10.4049/jimmunol.0900311
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
T cells are imprinted to express tissue-specific homing receptors upon activation in tissue-draining lymph nodes, resulting in their migration to the site of Ag entry. Expression of gut-homing molecules alpha(4)beta(7), and CCR9 is induced by retinoic acid, a vitamin A metabolite produced by retinal dehydrogenases, which are specifically expressed in dendritic cells as well as stromal cells in mucosa-draining lymph nodes. In this study, we demonstrate that mesenteric lymph node stromal cell-derived retinoic acid can directly induce the expression of gut-homing molecules on proliferating T cells, a process strongly enhanced by bone marrow-derived dendritic cells in vitro. Therefore, cooperation of sessile lymph node stromal cells with mobile dendritic cells warrants the imprinting of tissue specific homing receptors on activated T cells. The Journal of Immunology, 2009, 183: 6395-6402.
引用
收藏
页码：6395 / 6402
页数：8
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