The ECM as a driver of heart development and repair

被引：42

作者：

Derrick, Christopher J. ^{[1
]}

Noel, Emily S. ^{[1
]}

机构：

[1] Univ Sheffield, Dept Biomed Sci, Sheffield S10 2TN, S Yorkshire, England

来源：

DEVELOPMENT | 2021年 / 148卷 / 05期

关键词：

Cardiac morphogenesis; Extracellular matrix; Heart development; Heart regeneration; COPY-NUMBER VARIANTS; PROEPICARDIAL CELL-MIGRATION; CARDIAC-VALVE FORMATION; EXTRACELLULAR-MATRIX; ZEBRAFISH HEART; VERSICAN CLEAVAGE; MESENCHYMAL TRANSFORMATION; MYOCARDIAL MIGRATION; SULFATE EXPRESSION; HYALURONIC-ACID;

D O I：

10.1242/dev.191320

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The developing heart is formed of two tissue layers separated by an extracellular matrix (ECM) that provides chemical and physical signals to cardiac cells. While deposition of specific ECM components creates matrix diversity, the cardiac ECM is also dynamic, with modification and degradation playing important roles in ECM maturation and function. In this Review, we discuss the spatiotemporal changes in ECM composition during cardiac development that support distinct aspects of heart morphogenesis. We highlight conserved requirements for specific ECM components in human cardiac development, and discuss emerging evidence of a central role for the ECM in promoting heart regeneration.

引用

页数：17

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