Growth signaling in breast cancer cells: outcomes and promises of proteomics

被引：17
作者：
Adriaenssens, E
Lemoine, J
El Yazidi-Belkoura, I
Hondermarck, H
机构：
[1] Univ Lille 1, Lab Biol Dev, UPRES EA 1033, F-59650 Villeneuve Dascq, France
[2] Univ Sci & Technol Lille, Chim Biol Lab, UMR 8576, CNRS, Villeneuve Dascq, France
来源：
BIOCHEMICAL PHARMACOLOGY | 2002年 / 64卷 / 5-6期
关键词：
growth factors; oncogenes; breast cancer; signaling pathways; proteomics;
D O I：
10.1016/S0006-2952(02)01141-3
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Methods in functional proteomics are now used to study the intracellular signaling pathways that underlie the development of breast cancer. As shown with fibroblast growth factor-2, the oncogenic/non-coding mRNA H19 and 14-3-3 proteins, proteomics is a powerful approach to identify signaling proteins and to decipher the complex signaling circuitry involved in growth of breast cancer cells. Together with genomics, proteomics is now providing a way to define molecular processes involved in breast cancerogenesis and to identify new therapeutic targets. (C) 2002 Elsevier Science Inc. All rights reserved.
引用
收藏
页码：797 / 803
页数：7
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