Therapeutic effects of nitric oxide-aspirin hybrid drugs

被引：14

作者：

Turnbull, Catriona M.

Rossi, Adriano G.

Megson, Ian L. ^{[1
]}

机构：

[1] Univ Highlands and Islands, Free Rad Res Facil, Lifescan Chair Diabet, Inverness IV2 3BL, Scotland

[2] Univ Edinburgh, MRC, Ctr Inflammat Res, Queens Med Res Inst, Edinburgh EH16 4TJ, Midlothian, Scotland

[3] Univ Edinburgh, MRC, Ctr Cardiovasc Sci, Queens Med Res Inst, Edinburgh EH16 4TJ, Midlothian, Scotland

来源：

EXPERT OPINION ON THERAPEUTIC TARGETS | 2006年 / 10卷 / 06期

关键词：

analgesia; anti-inflammatory; aspirin; cancer; cardiovascular; gastrotoxicity; nitric oxide; NO-aspirin; NSAID; platelet;

D O I：

10.1517/14728222.10.6.911

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This review examines the therapeutic potential and mechanisms of action of drugs known as nitric oxide (NO)-aspirins. Drugs of this class have an NO-releasing moiety joined by ester linkage to the aspirin molecule. No-aspirins have the capability to release NO in addition to retaining the cyclooxygenase-inhibitory action of aspirin. The protective nature of NO led to the development of NO-aspirins in the hope that they might avoid the gastric side effects associated with aspirin. However, it has become apparent that the drug-derived NO instils potential for a wide range of added beneficial effects over the parent compound. in this review, the authors focus on the analgesic, anti-inflammatory, cardiovascular and chemopreventative actions of compounds of this emerging drug class.

引用

页码：911 / 922

页数：12

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