Evaluation of the anti-oxidant properties of a SOD-mimic Mn-complex in activated macrophages

被引：36

作者：

Bernard, Anne-Sophie ^{[1
,2
,4
]}

Giroud, Claire ^{[1
,2
,4
]}

Ching, H. Y. Vincent ^{[1
,2
,4
]}

Meunier, Anne ^{[1
,2
,5
]}

Ambike, Vinita ^{[3
]}

Amatore, Christian ^{[1
,2
,5
]}

Collignon, Manon Guille ^{[1
,2
,5
]}

Lemaitre, Frederic ^{[1
,2
,5
]}

Policar, Clotilde ^{[1
,2
,4
]}

机构：

[1] Ecole Normale Super, Dept Chim, F-75005 Paris, France

[2] Univ Paris 06, F-75005 Paris, France

[3] Univ Paris 11, Inst Chim Mol & Mat Orsay, F-91405 Orsay, France

[4] Univ Paris 11, CNRS, UMR7203, F-91405 Orsay, France

[5] Univ Paris 11, CNRS, UMR8640, F-91405 Orsay, France

来源：

DALTON TRANSACTIONS | 2012年 / 41卷 / 21期

关键词：

DISMUTASE-LIKE ACTIVITY; N-CENTERED LIGANDS; SUPEROXIDE-DISMUTASE; REACTIVE OXYGEN; MANGANESE COMPLEXES; ESCHERICHIA-COLI; OXIDATIVE STRESS; NITRIC-OXIDE; REAL-TIME; INFLAMMATION;

D O I：

10.1039/c2dt12479c

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

SOD-mimics are small complexes that reproduce the activity of superoxide dismutases, natural proteins that catalytically dismutate the superoxide anion. Activated macrophages, which produce ROS and RNS fluxes, constitute a relevant model to challenge antioxidant activity in a cellular context and were used to test a Mn-complex which was shown to efficiently alter the flow of O-2(-), ONOO- and H2O2.

引用

页码：6399 / 6403

页数：5

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