Mild ketone formation via Ni-catalyzed reductive coupling of unactivated alkyl halides with acid anhydrides

被引：128

作者：

Yin, Hongyu ^{[1
]}

Zhao, Chenglong ^{[1
]}

You, Hengzhi ^{[1
]}

Lin, Kunhua ^{[1
]}

Gong, Hegui ^{[1
]}

机构：

[1] Shanghai Univ, Dept Chem, Shanghai 200444, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2012年 / 48卷 / 56期

关键词：

ARYL HALIDES; ORGANOZINC REAGENTS; ALLYLIC ACETATES; CARBOXYLIC-ACIDS; CROSS-COUPLINGS; ACYL CHLORIDES; THIOL ESTERS; PALLADIUM; BROMIDES; COBALT;

D O I：

10.1039/c2cc33232a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Ni-catalyzed ketone formation through mild reductive coupling of a diverse set of unactivated alkyl bromides and iodides with particularly aryl acid anhydrides was successfully developed using zinc as the terminal reductant. These conditions also allow direct coupling of alkyl iodides with aryl acids in the presence of Boc(2)O and MgCl2.

引用

页码：7034 / 7036

页数：3

共 53 条

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