Phenolic Compounds Isolated from Psoralea corylifolia Inhibit IL-6-induced STAT3 Activation

被引:91
作者
Lee, Seung Woong [1 ]
Yun, Bo Ra [1 ]
Kim, Mi Hwa [1 ]
Park, Chan Sun [1 ]
Lee, Woo Song [1 ]
Oh, Hyun-Mee [1 ]
Rho, Mun-Chual [1 ]
机构
[1] KRIBB, Bioind Proc Res Ctr, Biomat Res Inst, Jeongeup Si 580185, Jeonbuk, South Korea
基金
新加坡国家研究基金会;
关键词
Psoralea corylifolia L; Fabaceae; flavonoids; IL-6; STAT3; anti-inflammatory; IN-VITRO; SEEDS;
D O I
10.1055/s-0031-1298482
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Inhibiting interleukin-6 (IL-6) has been postulated as an effective therapy in the pathogenesis of several inflammatory diseases. In this study, seven flavonoids were isolated from the methanol ex-tracts of Psoralea corylifolia by bioactivity-guided fractionation. The structures of bakuchiol (1), bavachinin (2), neobavaisoflavone (3), corylifol A (4), corylin (5), isobavachalcon (6), and bavachin (7) were determined by spectroscopic analysis (H-1-, (CNMR)-C-13 and MS). We demonstrated that compounds 1-7 showed an inhibitory effect on IL-6-induced STAT3 promoter activity in Hep3B cells with IC50 values of 4.57 +/- 0.45, 3.02 +/- 0.53, 2.77 +/- 0.02, 0.81 +/- 0.15, 1.37 +/- 0.45, 2.45 +/- 0.13, and 4.89 +/- 0.05 mu m, respectively. These compounds also inhibited STAT3 phosphorylation induced by IL-6 in Hep3B cells. Overall, several flavonoids from P. corylifolia might be useful remedies for treating inflammatory diseases by inhibiting IL-6-induced STAT3 activation and phosphorylation.
引用
收藏
页码:903 / 906
页数:4
相关论文
共 17 条
[1]   Inflammatory cytokines impair endothelium-dependent dilatation in human veins in vivo [J].
Bhagat, K ;
Vallance, P .
CIRCULATION, 1997, 96 (09) :3042-3047
[2]   Bavachin and Isobavachalcone, Acyl-coenzyme A: Cholesterol Acyltransferase Inhibitors from Psoralea corylifolia [J].
Choi, Jung Ho ;
Rho, Mun-Chual ;
Lee, Seung Woong ;
Choi, Ji Na ;
Kim, Koanhoi ;
Song, Gyu Young ;
Kim, Young Kook .
ARCHIVES OF PHARMACAL RESEARCH, 2008, 31 (11) :1419-1423
[3]   A High-Affinity Fully Human Anti-IL-6 mAb, 1339, for the Treatment of Multiple Myeloma [J].
Fulciniti, Mariateresa ;
Hideshima, Teru ;
Vermot-Desroches, Claudine ;
Pozzi, Samantha ;
Nanjappa, Puru ;
Shen, Zhenxin ;
Patel, Nipun ;
Smith, Ernest S. ;
Wang, Wei ;
Prabhala, Rao ;
Tai, Yu-tzu ;
Tassone, Pierfrancesco ;
Anderson, Kenneth C. ;
Munshi, Nikhil C. .
CLINICAL CANCER RESEARCH, 2009, 15 (23) :7144-7152
[4]   Inhibition of mitochondrial lipid peroxidation by bakuchiol, a meroterpene from Psoralea corylifolia [J].
Haraguchi, H ;
Inoue, J ;
Tamura, Y ;
Mizutani, K .
PLANTA MEDICA, 2000, 66 (06) :569-571
[5]   In vitro protein tyrosine phosphatase 1B inhibitory phenols from the seeds of Psoralea corylifolia [J].
Kim, YC ;
Oh, H ;
Kim, BS ;
Kang, TH ;
Ko, EK ;
Han, YM ;
Kim, BY ;
Ahn, JS .
PLANTA MEDICA, 2005, 71 (01) :87-89
[6]  
Kim Y, 2009, B KOREAN CHEM SOC, V30, P1867
[7]   Prenylflavones from Psoralea corylifolia inhibit nitric oxide synthase expression through the inhibition of I-κB-α degradation in activated microglial cells [J].
Lee, MH ;
Kim, JY ;
Ryu, JH .
BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2005, 28 (12) :2253-2257
[8]  
Li HC, 2003, ACTA PHARMACOL SIN, V24, P1131
[9]  
LUGER TA, 1989, ANN NY ACAD SCI, V557, P405
[10]  
Mori Akio, 2007, Rinsho Ketsueki, V48, P559