Phenolic Compounds Isolated from Psoralea corylifolia Inhibit IL-6-induced STAT3 Activation

被引：91

作者：

Lee, Seung Woong ^{[1
]}

Yun, Bo Ra ^{[1
]}

Kim, Mi Hwa ^{[1
]}

Park, Chan Sun ^{[1
]}

Lee, Woo Song ^{[1
]}

Oh, Hyun-Mee ^{[1
]}

Rho, Mun-Chual ^{[1
]}

机构：

[1] KRIBB, Bioind Proc Res Ctr, Biomat Res Inst, Jeongeup Si 580185, Jeonbuk, South Korea

来源：

PLANTA MEDICA | 2012年 / 78卷 / 09期

基金：

新加坡国家研究基金会;

关键词：

Psoralea corylifolia L; Fabaceae; flavonoids; IL-6; STAT3; anti-inflammatory; IN-VITRO; SEEDS;

D O I：

10.1055/s-0031-1298482

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Inhibiting interleukin-6 (IL-6) has been postulated as an effective therapy in the pathogenesis of several inflammatory diseases. In this study, seven flavonoids were isolated from the methanol ex-tracts of Psoralea corylifolia by bioactivity-guided fractionation. The structures of bakuchiol (1), bavachinin (2), neobavaisoflavone (3), corylifol A (4), corylin (5), isobavachalcon (6), and bavachin (7) were determined by spectroscopic analysis (H-1-, (CNMR)-C-13 and MS). We demonstrated that compounds 1-7 showed an inhibitory effect on IL-6-induced STAT3 promoter activity in Hep3B cells with IC50 values of 4.57 +/- 0.45, 3.02 +/- 0.53, 2.77 +/- 0.02, 0.81 +/- 0.15, 1.37 +/- 0.45, 2.45 +/- 0.13, and 4.89 +/- 0.05 mu m, respectively. These compounds also inhibited STAT3 phosphorylation induced by IL-6 in Hep3B cells. Overall, several flavonoids from P. corylifolia might be useful remedies for treating inflammatory diseases by inhibiting IL-6-induced STAT3 activation and phosphorylation.

引用

页码：903 / 906

页数：4

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