Galectin-3-a New Biomarker for Diagnostics and Outcome of Chronic Heart Failure

被引：0

作者：

Lakomkin, S. V. ^{[1
]}

Skvortsov, A. A. ^{[1
]}

Goryunova, T. V. ^{[1
]}

Masenko, V. P. ^{[1
]}

Tereshchenko, S. N. ^{[1
]}

机构：

[1] Russian Minist Hlth, Moscow 121552, Russia

来源：

KARDIOLOGIYA | 2012年 / 52卷 / 03期

关键词：

galectin-3; lectines; fibrosis; heart remodeling; biomarkers; heart failure; prognosis; NT-proBNP; GALECTIN-3/AGE-RECEPTOR-3 KNOCKOUT MICE; EXTRACELLULAR-MATRIX TURNOVER; AMINO-TERMINAL PROPEPTIDE; III PROCOLLAGEN; ATHEROSCLEROTIC LESIONS; HEPATIC-FIBROSIS; PROGNOSTIC VALUE; IMMUNE-RESPONSE; BINDING-PROTEIN; AGE-RECEPTOR;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Galectins - lectins binding beta-galactosides their properties and biological role have been described. Galectines family in mammalians consists of 15 members. Galectin-3 is atypical specimen of galectin's family. It's participation in fibrosis, cardiac remodeling, immune and inflammation responses have been shown. Employment galectin-3 as new independent biomarker for diagnosis of acute heart failure and outcome predictor in patients with chronic heart failure (HF) are discussed. Diagnostic and prognostic values of galectin-3 are compared with famous and wide using HF marker NT-proBNP. Combined employing biomarkers for diagnostic and prognostic purpose of HF have been discussed. Using galectin-3 as therapeutic target in treatment of chronic HF in future is suggested.

引用

页码：45 / 52

页数：8

共 63 条

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