Arrestin NK cell cytotoxicity

被引:4
作者
Bryceson, Yenan T. [1 ,2 ]
Ljunggren, Hans-Gustaf [1 ]
机构
[1] Karolinska Univ Hosp Huddinge, Karolinska Inst, Dept Med, Ctr Infect Med, S-14186 Stockholm, Sweden
[2] NIAID, Immunogenet Lab, NIH, Rockville, MD 20852 USA
关键词
D O I
10.1038/ni0808-835
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
A key regulator of the balance of signals that activate effector mechanisms versus those that restrain them, beta-arrestin 2 mediates the inhibition of natural killer cell cytotoxicity.
引用
收藏
页码:835 / 836
页数:2
相关论文
共 11 条
[1]   Determination of the binding specificity of the SH2 domains of protein tyrosine phosphatase SHP-1 through the screening of a combinatorial phosphotyrosyl peptide library [J].
Beebe, KD ;
Wang, P ;
Arabaci, G ;
Pei, DH .
BIOCHEMISTRY, 2000, 39 (43) :13251-13260
[2]   Line of attack: NK cell specificity and integration of signals [J].
Bryceson, Yenan T. ;
Long, Eric O. .
CURRENT OPINION IN IMMUNOLOGY, 2008, 20 (03) :344-352
[3]   Recruitment of tyrosine phosphatase HCP by the killer cell inhibitory receptor [J].
Burshtyn, DN ;
Scharenberg, AM ;
Wagtmann, N ;
Rajagopalan, S ;
Berrada, K ;
Yi, TL ;
Kinet, JP ;
Long, EO .
IMMUNITY, 1996, 4 (01) :77-85
[4]   β-arrestins and cell signaling [J].
DeWire, Scott M. ;
Ahn, Seungkirl ;
Lefkowitz, Robert J. ;
Shenoy, Sudha K. .
ANNUAL REVIEW OF PHYSIOLOGY, 2007, 69 :483-510
[5]   Crystal structure of the tyrosine phosphatase SHP-2 [J].
Hof, P ;
Pluskey, S ;
Dhe-Paganon, S ;
Eck, MJ ;
Shoelson, SE .
CELL, 1998, 92 (04) :441-450
[6]  
LONG EO, IMMUNOL REV IN PRESS
[7]   Impaired natural killing of MHC class I-deficient targets by NK cells expressing a catalytically inactive form of SHP-1 [J].
Lowin-Kropf, B ;
Kunz, B ;
Beermann, F ;
Held, W .
JOURNAL OF IMMUNOLOGY, 2000, 165 (03) :1314-1321
[8]  
Olcese L, 1996, J IMMUNOL, V156, P4531
[9]   Immune inhibitory receptors [J].
Ravetch, JV ;
Lanier, LL .
SCIENCE, 2000, 290 (5489) :84-89
[10]   Vav1 dephosphorylation by the tyrosine phosphatase SHP-1 as a mechanism for inhibition of cellular cytotoxicity [J].
Stebbins, CC ;
Watzl, C ;
Billadeau, DD ;
Leibson, PJ ;
Burshtyn, DN ;
Long, EO .
MOLECULAR AND CELLULAR BIOLOGY, 2003, 23 (17) :6291-6299