Expert opinion: Responsive polymer nanoparticles in cancer therapy

被引：165
作者：
Liechty, William B. [2 ]
Peppas, Nicholas A. [1 ,2 ,3 ]
机构：
[1] Univ Texas Austin, Dept Biomed Engn, Austin, TX 78731 USA
[2] Univ Texas Austin, Dept Chem Engn, Austin, TX 78731 USA
[3] Univ Texas Austin, Coll Pharm, Austin, TX 78731 USA
来源：
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS | 2012年 / 80卷 / 02期
基金：
美国国家科学基金会; 美国国家卫生研究院;
关键词：
Drug delivery; pH-responsive polymers; Cancer therapy; Nanoparticles; Nanogels; Polymer micelles; POLY(BETA-AMINO ESTER) NANOPARTICLES; TUMOR-TARGETED DELIVERY; PH-SENSITIVE SYSTEM; DRUG-DELIVERY; HYDROPHOBIC DRUGS; IN-VITRO; DESIGN; THERAPEUTICS; RELEASE; BIODISTRIBUTION;
D O I：
10.1016/j.ejpb.2011.08.004
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Polymeric nanoparticles are emerging as an attractive treatment options for cancer due to their favorable size distribution, drug carrying capacity, and tunable properties. In particular, intelligent nanoparticles that respond to biological cues are of interest because of their ability to provide controlled release at a specific site. Tumor sites display abnormal pH profiles and pathophysiology that can be exploited to provide localized release. In this expert opinion, we discuss passive and active targeting of nanoparticles and several classes of pH-responsive nanoparticles. (C) 2011 Elsevier B.V. All rights reserved.
引用
收藏
页码：241 / 246
页数：6
相关论文
共 56 条
[1]   Factors affecting the clearance and biodistribution of polymeric nanoparticles [J].
Alexis, Frank ;
Pridgen, Eric ;
Molnar, Linda K. ;
Farokhzad, Omid C. .
MOLECULAR PHARMACEUTICS, 2008, 5 (04) :505-515
[2]   Design of environment-sensitive supramolecular assemblies for intracellular drug delivery: Polymeric micelles that are responsive to intracellular pH change [J].
Bae, Y ;
Fukushima, S ;
Harada, A ;
Kataoka, K .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2003, 42 (38) :4640-4643
[3]  
Bhavsar M.D., 2006, NANOPARTICULATES DRU
[4]   Oral chemotherapeutic delivery: Design and cellular response [J].
Blanchette, J ;
Peppas, NA .
ANNALS OF BIOMEDICAL ENGINEERING, 2005, 33 (02) :142-149
[5]   Nanoparticle and targeted systems for cancer therapy [J].
Brannon-Peppas, L ;
Blanchette, JO .
ADVANCED DRUG DELIVERY REVIEWS, 2004, 56 (11) :1649-1659
[6]   Nanoparticles in cancer therapy and diagnosis [J].
Brigger, I ;
Dubernet, C ;
Couvreur, P .
ADVANCED DRUG DELIVERY REVIEWS, 2002, 54 (05) :631-651
[7]   Active targeting schemes for nanoparticle systems in cancer therapeutics [J].
Byrne, James D. ;
Betancourt, Tania ;
Brannon-Peppas, Lisa .
ADVANCED DRUG DELIVERY REVIEWS, 2008, 60 (15) :1615-1626
[8]  
Cassidy Jim, 2004, Expert Reviews in Molecular Medicine, V6, P1, DOI 10.1017/S1462399404008269
[9]   Synthesis and pH-responsive properties of pseudo-peptides containing hydrophobic amino acid grafts [J].
Chen, Rongjun ;
Eccleston, Mark E. ;
Yue, Zhilian ;
Slater, Nigel K. H. .
JOURNAL OF MATERIALS CHEMISTRY, 2009, 19 (24) :4217-4224
[10]   The role of hydrophobic amino acid grafts in the enhancement of membrane-disruptive activity of pH-responsive pseudo-peptides [J].
Chen, Rongjun ;
Khormaee, Sariah ;
Eccleston, Mark E. ;
Slater, Nigel K. H. .
BIOMATERIALS, 2009, 30 (10) :1954-1961
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