Interactions of single-stranded DNA on microcantilevers

被引：30

作者：

Zhang, N. H. ^{[1
,2
,3
]}

Tan, Z. Q. ^{[1
,3
]}

Li, J. J. ^{[1
,2
,3
]}

Meng, W. L. ^{[1
,3
]}

Xu, L. W. ^{[1
,3
]}

机构：

[1] Shanghai Univ, Shanghai Inst Appl Math & Mech, Shanghai 200072, Peoples R China

[2] Shanghai Univ, Coll Sci, Dept Mech, Shanghai 200072, Peoples R China

[3] Shanghai Key Lab Mech Energy Engn, Shanghai 200072, Peoples R China

来源：

CURRENT OPINION IN COLLOID & INTERFACE SCIENCE | 2011年 / 16卷 / 06期

基金：

中国国家自然科学基金; 美国国家科学基金会;

关键词：

Single-stranded DNA interactions; Microcantilever sensors; Two-variable method; Surface stress; BIOMOLECULAR ELECTROSTATICS; SURFACE STRESS; DEFLECTION; TENSION; MODEL; NANOMECHANICS; HYBRIDIZATION; MOLECULES; EQUATION; ORIGIN;

D O I：

10.1016/j.cocis.2011.04.013

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The microcantilever approach has attracted considerable attention in recent years as a means of label-free detection of a variety of biomolecular and chemical reactions. The underlying physics of the intermolecular interactions that result in mechanical motions is yet to be fully explored, but it seems both rich in science and of technological importance. This paper presents an overview of experiments and theories related to interactions of single-stranded DNA immobilized on microcantilevers. Experiments and theories show that, at high grafting density, hydration forces are the dominant factor determining cantilever deflections, not electrostatics or conformational entropy. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：592 / 596

页数：5

共 53 条

[1] Nanomechanics of the formation of DNA self-assembled monolayers and hybridization on microcantilevers [J].